Cedars-Sinai Biobank and Translational Research Core Facility (CS-BRCF)

描述（由申请人提供）：雪松-西奈医疗中心最近完成了耗资1500万美元的SS大楼（SSB）的抗震升级，该大楼目前是一个多功能设施。我们现在请求美国国立卫生研究院与我们合作，将SSB中的空间重新定向用于转化研究目的。具体来说，我们建议翻新现有空间，建立一个集中的、共享的核心生物库研究设施：雪松-西奈生物库和转化研究核心设施（CS- BRCF）。我们有4个目标：1)建立一个核心研究设施，在密切监督下，使用最佳实践的标准化方式收集生物标本用于研究；2)创建一个强大的全系统医疗信息平台，将患者数据和结果与每个生物标本联系起来，使用最先进的资本软件和硬件，完全符合GLP、GFP、HIPAA和IRB法规所要求的更高的监管和隐私要求，实现“从摇篮到坟墓”的跟踪，并与caBIG平台兼容；3)在CS-BRCF内建立质量评估、形态学和分子核心实验室（QA- mmc），在组织标本存档前对其进行表征，提供病理学家专业知识，执行分析物QA/QC，并部署和完善标本采集、处理、存档和检索的最佳程序；4)将遗留生物储存库聚集到一个单一的受控安全设施中。拟议的6322平方英尺的CS-BRCF将监督和便利研究者获取生物标本。此外，CS-BRCF将优化实验室空间和人员利用效率，从而释放空间和人员，直接重新部署到研究应用中。CS-BRCF将促进不同研究者之间的协作互动，从而刺激研究和资助申请。整个设施都采用了可持续的设计考虑。在任何可能的情况下，能源效率低下的冷冻机将被最小化或丢弃，取而代之的是更可持续的液氮气相储存技术。我们预计在设计和许可阶段将创造/维持9个工作岗位（工资中位数$85,000），在10个月的施工阶段将创造/维持66个工作岗位（工资中位数$55,000），在开始运营并无限期维持或扩展时将创造11个长期工作岗位（工资中位数$81,000）。CS-BRCF的运营和维护还将创造9个新的支持性工作岗位，工资中位数为6万美元。届时，美国将总共创造95个就业岗位，总年薪中位数为582.6万美元。因此，CS-BRCF将创造持续的就业机会，利用“绿色”技术和设计原则（预计LEED银级），并加快基于生物标本的转化研究的步伐，这将是21世纪向个性化医疗过渡的核心重要因素。

DESCRIPTION (provided by applicant): Cedars-Sinai Medical Center has recently completed a $15 million seismic upgrade to the SS Building (SSB), currently a mixed-use facility. We now request the NIH to partner with us to redirect space in SSB for translational research purposes. Specifically, we propose to renovate existing space to build a centralized, shared core biobank research facility: the Cedars-Sinai Biobank and Translational Research Core Facility (CS- BRCF). We have 4 objectives: 1) To create a core research facility to collect biospecimens prospectively for research use in a closely-supervised, standardized fashion using Best Practices; 2) To create a robust system- wide medical informatics platform that will link patient data and outcomes to each biospecimen using state-of- the-art capital software and hardware that is fully compliant with heightened regulatory and privacy requirements necessitated by GLP, GFP, HIPAA, and IRB regulations, enables "cradle to grave" tracking, and is compatible with the caBIG platform; 3) To create a Quality Assessment, Morphology, and Molecular Core Laboratory (QA-MMC) within the CS-BRCF that will characterize tissues specimens before archiving, provide pathologist expertise, perform analyte QA/QC, and deploy and refine optimal procedures for specimen acquisition, processing, archiving, and retrieval; and 4) To aggregate legacy biorepositories into a single controlled, secure facility. The proposed 6,322 net sq ft CS-BRCF will oversee and facilitate investigator access to biospecimens. Further, the CS-BRCF will optimize efficiencies of laboratory space and personnel utilization, which in turn will free up both space and personnel for re-deployment directly into research applications. The CS-BRCF will promote collaborative interactions among disparate investigators, and will thus stimulate research and grant applications. Sustainable design considerations are employed throughout the facility. Wherever possible, energy-inefficient freezers will be minimized or discarded in favor of more sustainable liquid nitrogen vapor-phase storage technology. We project that 9 jobs (median salary $85,000) will be created/sustained during the design and permitting phase, 66 jobs (median salary $55,000) will be created/sustained during the 10-month construction phase, and 11 long-term jobs (median salary $81,000) will be created upon beginning operations and maintained or expanded indefinitely. Operation and maintenance of the CS-BRCF will also create 9 new support jobs, with median salaries of $60,000. In total then, 95 American jobs will be created with total annual median salaries of $5,826,000. The CS-BRCF will thus create sustained employment, utilize "Green" technologies and design principles (projected LEED Silver rating), and accelerate the pace of the biospecimen-based translational research that will be centrally important in transitioning towards personalized medical care in the 21st century.