Renovation of the Wells Research Center for a Pediatric Phenotyping Core

描述（由申请人提供）：本项目的目标是大幅提高儿童健康研究设施，并在印第安纳州大学建立儿科表型实验室和患者研究资源的核心设施。儿童健康研究和评估设施（CHREF）核心将是位于莱利儿童医院的旗舰儿科研究设施。它将是印第安纳州大学医学院进行的大多数儿科患者导向研究的主要地点。该项目有以下具体目标：具体目标1：创建一个全面的儿童健康研究核心，致力于研究参与者的最先进的表型和临床评估。具体目标二：建立新技术的共享资源，以连接和加强不同临床研究科学家群体之间的合作。具体目标3：翻新现有的18560 gsf陈旧的实验室空间，儿科学科评估资源和相关的支持空间。拟议中的项目翻新空间在威尔斯儿科研究中心在莱利儿童医院，这是位于二楼的现有28,000两层楼高的建筑，最初建于20世纪60年代。拟议的项目将在第二层翻修约18 500个一般安全设施，用于计划中的CHREF所需的研究实验室和门诊检查设施。该地区的主要部分将被拆除，并转换为最先进的研究实验室，旨在促进工作研究小组之间的互动。拟议的项目将对研究具有各种疾病状态的健康儿科受试者的不同水平产生变革性影响。它将把一系列现有的儿科实验室项目整合到一个核心中，以创建真正协作的、定量的疾病表型及其治疗方法。关于其经济影响，它将创造大量的建筑工作，并支持和维持25个全职医疗保健工作。

DESCRIPTION (provided by applicant): This goal of this project is to substantially enhance the children's health research facilities and to create a core facility of pediatric phenotyping laboratories and patient research resource at Indiana University. The Children's Health Research and Evaluation facility (CHREF) core will be the flagship pediatrics research facility located in Riley Children's Hospital. It will be the primary site for most of the pediatric patient oriented research done at Indiana University School of Medicine. The project has the following Specific Aims: Specific Aim 1: To create a comprehensive child health research core dedicated to state-of-the art phenotyping and clinical assessment of research participants. Specific Aim 2: To establish shared resources of novel technologies to connect and enhance collaborations between the diverse groups of clinical research scientists. Specific Aim 3: To renovate 18560 gsf of existing outdated laboratory space, pediatrics subject assessment resources and associated support space. The proposed project renovates space in the Wells Pediatric Research Center at Riley Hospital for Children, which is located on the second floor of an existing 28,000 two-story building, originally constructed in the 1960's. The proposed project renovates approximately 18,500 GSF on the second level for research laboratories and outpatient examination facilities as required for the planned CHREF. A major part of the area will be gutted and converted to state of the art research laboratories designed to promote interaction between working research groups. The proposed project will have a transformative effect on the different levels of studying both healthy pediatric subjects with a variety disease states. It will bring together a range of existing pediatrics laboratory programs into a single core to create truly collaborative, quantitative phenotyping of diseases and their treatments. With regards to its economic impact, it will create a significant number of constructions jobs and support and sustain 25 full time health care jobs.