Core Facilities Improvement: Forsyth Data Center Renovation

描述（由申请人提供）：福赛斯研究所，世界领先的口腔和颅面疾病研究，要求1，218，232美元翻新606平方英尺的新的最先进的数据中心核心在其新的研究设施在245第一街，剑桥，马萨诸塞州。该数据中心将支持新的主机生物膜界面发现中心（CHBI）的研究以及该研究所的许多其他基础和临床研究项目。该项目代表了我们数据中心能力的重大扩展，因为我们准备为福赛斯生物信息学核心托管新的192核Beowulf集群。目前正在开展一项积极的活动，招募新的年轻科学家作为主要研究人员，他们将与我们现有的研究优势协同作用，并将在理解人类如何与他们的微生物乘客共存方面产生巨大的新进展健康，以及宿主生物膜界面的扰动如何导致疾病。这些青年科学家将具有以下领域的专门知识：人类遗传学/基因组学和蛋白质组学;唾液生物学;微生物-上皮相互作用;免疫系统的个体发生;粘膜表面的调节机制;粘膜形成;微生物-矿化组织相互作用;和临床/转化研究，特别是与糖尿病、代谢综合征、肥胖症、心血管疾病炎症性肠病、早产和其他疾病。CHBI将进一步整合到新资助的哈佛CTSC（“CATALYST”，http：catalyst.harvard.edu）和哈佛系统生物学中心。福赛斯将受到这一方案扩展影响的资金为：14，267，072美元（46个正在进行的项目）和四十二（42）个待决项目（12，893，999美元）。据我们所知，CHBI在口腔健康领域将是独一无二的，并将使福赛斯将其在该领域的长期领导地位提高到一个新的水平。从2010年春季开始，福赛斯将开始其新租赁的设施位于245第一街，剑桥马位于肯德尔广场附近的麻省理工学院。预计翻修工作将持续到夏季大部分时间和秋季。研究所将租用该空间至少15年，并有两个额外的5年选择。这保证了我们对翻新空间的长期占用。由于福赛斯现有的计划搬迁本身将独立于ARRA建设赠款资金，因此本申请仅请求对新数据中心的支持，以准备我们的搬迁。新的数据中心改造已经“准备就绪”，必须在2010年秋季完成。该项目涉及一些美国创造就业机会，包括立即创造约11个就业机会的影响，如果这个应用程序得到资助。

DESCRIPTION (provided by applicant): The Forsyth Institute, the world's leader in oral and craniofacial disease research, requests $1,218,232 to renovate 606 ft2 for a new state-of-the-art data center core at its new research facility at 245 First Street, Cambridge, MA. The data center will support the research of the new Center for Discovery at the Host-Biofilm Interface (CHBI) and many of the other basic and clinical research programs at the Institute. This project represents a significant expansion of our data center capabilities as we prepare to host the new 192- core Beowulf Cluster for the Forsyth Bioinformatics Core. An aggressive campaign is currently underway to recruit new young scientists as principal investigators who will synergize with our existing research strengths and will generate dramatic new advances in understanding how humans co-exist with their microbial passengers in health, and how perturbations at the host-biofilm interface lead to disease. These young scientists will have expertise in the following areas: human genetics/genomics and proteomics; salivary biology; microbial-epithelial interactions; ontogeny of the immune system; regulatory mechanisms at mucosal surfaces; establishment of commensalism; microbial-mineralized tissue interactions; and clinical/translational research particularly relating to oral-systemic disease interactions in diabetes, metabolic syndrome, obesity, cardiovascular disease, inflammatory bowel diseases, premature birth, and others. The CHBI will be further integrated as appropriate into the newly funded Harvard-wide CTSC ('CATALYST', http:catalyst.harvard.edu), and the Harvard Center for Systems Biology. The funding at Forsyth that will be impacted by this programmatic expansion is: $14,267,072 (46 active projects), and forty-two (42) pending projects ($12,893,999). To our knowledge, the CHBI will be unique in the field of oral health, and will allow Forsyth to bring its long leadership in this field to a new level. Beginning in the spring of 2010, Forsyth will begin significant renovation of its newly-leased facility located at 245 First Street, Cambridge MA located in the Kendall Square area near MIT. It is expected that renovations will continue through much of the summer and into the Fall. The Institute will lease the space for a minimum of 15 years, with two additional 5-year options. This guarantees our long-term occupancy of the renovated space. Because Forsyth's existing program relocation per se will occur independent of ARRA construction grant funding, this application requests support only for the new data center in preparation for our move. The new data center renovation is 'shovel ready' and must be completed in the Fall of 2010. The project involves some U.S. job creation including an immediate job impact of approximately 11 jobs created should this application be funded.