VANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced Genomics

描述(由申请人提供)：范德比尔特大学医学院认识到将基因组科学的进步转化为改善人类健康的重要性，已承诺通过共享资源设施提供最先进的实验室环境和技术。为此，这项赠款申请的目的是通过将多个目前物理上分离的研究资源整合到一个中央位置的共享资源：Vantage(Vanderbilt Technologies for Advanced基因组学)，优化有利于合作和加速新的生物和临床发现的环境。通过对现有的9,316平方英尺老化、利用率低下的实验室空间进行全面现代化改造，该提案将为Genome Technology Core(GTC，下一代技术开发的协作核心)和BioVU(目前位于DNA Resources Core内的Vanderbilt DNA Repository)创建一个实体之家，并将整合和扩展现有的四个核心设施：DNA Resources Core、DNA测序核心、Vanderbilt微阵列共享资源(VMSR)和流式细胞术核心。一旦翻新完成，这些不同的研究资源中的每一个都将共享合作空间，从而通过扩大和加强已经成功的合作，在基因组学研究中创造一个发现的制度网络。Vantage将实现技术协同，消除不必要的重复，并加快整个机构在临床和基础科学方面的发现。特别是，这次翻修将影响范德比尔特公司主要用户提供的968多笔正在进行的赠款，涉及每年约2.35亿美元的直接成本。

DESCRIPTION (provided by applicant): Recognizing the importance of translating advances in genome science to improved human health, Vanderbilt University School of Medicine has made a commitment to provide state-of-the art laboratory environments and technology through shared resource facilities. To that end, the purpose of this grant application is to optimize an environment conducive to collaboration and acceleration of new biological and clinical discoveries through consolidation of multiple currently physically separate research resources into a centrally located shared resource: VANTAGE (VANderbilt Technologies for Advanced GEnomics). Through complete modernization of an existing 9,316 Net Square Feet of aging, poorly-utilized laboratory space, this proposal will create a physical home for the Genome Technology Core (GTC, a collaborative core for development of next-generation technologies) and BioVU (the Vanderbilt DNA Repository currently housed within the DNA Resources Core), and will enable the consolidation and expansion of four existing core facilities: DNA Resources Core, DNA Sequencing Core, Vanderbilt Microarray Shared Resource (VMSR) and the Flow Cytometry Core. Once renovation is complete, each of these distinct research resources will share collaborative space, thereby creating an institutional nexus of discovery in genomics research by extending and strengthening already successful collaborations. VANTAGE will enable technical synergy, eliminate unnecessary duplication and accelerate discovery in clinical and basic science across the institution. In particular, this renovation will impact over 968 active grants from major Vanderbilt users involving approximately 235 million in annual direct costs.