Cancer Center Support Grant

描述（由申请人提供）：这是范德比尔特-英格拉姆癌症中心（VICC） CCSG的第二个竞争性延续申请。VICC是范德比尔特大学医学中心（VUMC）内的一个矩阵中心，VICC整合了医学院、护理学院、艺术与科学学院、工程学院、皮博迪教育学院以及完全整合的退伍军人管理医疗中心（VAMC）的癌症相关专业知识和资源。所有的设施都位于同一个校园，这种情况促进了互动、资源共享和合作。VICC成立于1993年，是一个具有超部门地位的组织单位。VICC的具体权限和职责是：1)协调和整合范德比尔特大学的癌症及癌症相关活动；2)进行、支持和加强癌症研究，并在大学内整合与癌症有关的活动；3)整合、发展和开展癌症教育项目；4)协调和整合VUMC和VAMC的癌症患者护理。研究目标是通过七个研究项目来完成的，这些研究项目与之前的申请基本相同，只是名称略有变化。这些项目包括：信号转导和细胞增殖，癌症蛋白质组学和基因组学，宿主-肿瘤相互作用，胃肠道癌症，乳腺癌，癌症预防和基于人群的研究，以及实验治疗。提出了16个共享资源，代表8个以前支持的资源和8个新支持的资源。在过去的项目期间，VICC的发展取得了显著的进展。该中心已更名为范德比尔特-英格拉姆癌症中心，这是基于英格拉姆家族发起的一项资本运动的大量慈善基金的承诺。此次集资活动的资金与机构资金相结合，招募了80名新教师，加强了VICC的所有研究项目，设立了20个特聘教授职位，用于招聘和保留，扩大了VICC控制和利用的空间，并建立了尖端的基因组学，蛋白质组学和信息学共享资源。通过招募12名癌症流行病学家，建立了一项大规模的基于人群的研究计划，这些流行病学家现在领导着VICC新资助的三个主要队列：南方社区队列、上海女性队列和上海男性队列。三个NCI SPORE拨款已经获得资助，NCI资助VICC的资金基础自上次续期以来增加了2.9倍。

DESCRIPTION (provided by applicant): This is the second competing continuation application for the Vanderbilt-Ingram Cancer Center (VICC) CCSG. The VICC is a matrix center within Vanderbilt University Medical Center (VUMC), and the VICC integrates the cancer-related expertise and resources of the School of Medicine, School of Nursing, School of Arts and Sciences, School of Engineering, and Peabody School of Education as well as the fully integrated Veterans Administration Medical Center (VAMC). All facilities are located on the same campus, a situation that promotes interactions, sharing of resources, and collaborations. Established in 1993, the VICC functions as an organizational unit with a supradepartmental status. The VICC's specific authorities and responsibilities are: 1) to conduct coordinate and integrate the cancer and cancer-related activities of Vanderbilt University; 2) to conduct, support and enhance cancer research and to integrate cancer-related activities throughout the University; 3) to integrate, develop and conduct cancer education programs; and 4) to coordinate and integrate the care of cancer patients at VUMC and VAMC. The research objectives are accomplished through seven Research Programs that are essentially the same as in the previous application with minor name changes. The Programs are: Signal Transduction and Cell Proliferation, Cancer Proteomics and Genomics, Host-Tumor Interactions, Gastrointestinal Cancer, Breast Cancer, Cancer Prevention and Population-Based Research, and Experimental Therapeutics. Sixteen Shared Resources are proposed representing eight previously supported and eight new. There has been remarkable progress in the development of the VICC over the past project period. The Center has been renamed the Vanderbilt-Ingram Cancer Center based on a substantial commitment of philanthropic funds from the Ingram family that initiated a capital campaign. Funds from the capital campaign have been leveraged with Institutional funds to recruit 80 new faculty enhancing all of the VICC Research Programs, establish 20 endowed professorships for recruitment and retention, expand space controlled and utilized by the VICC, and establish cutting-edge genomic, proteomic and informatics shared resources. A large population-based research initiative was established through recruitment of 12 cancer epidemiologists who now head three newly funded major cohorts based at the VICC, the Southern Community Cohort, the Women's Shanghai Cohort, and the Men's Shanghai Cohort. Three NCI SPORE grants have been funded, and the NCI funding base for the VICC has increased 2.9 fold since the last renewal.