Inhaled Aerosol Dosimetry: Advances, Applications, and Impacts on Risk Assessments and Therapeutics

项目摘要/摘要 新冠肺炎大流行暴露了我们对传染性病毒剂通过空气传播的严重缺乏了解。 对气溶胶的沉积、代谢、在体内的分布和损伤机制的了解不足 (悬浮在气体中的颗粒)限制了制定空气质量标准和开发新的可吸入气体的信心 治疗学。由于个体差异，人们对吸入剂量(例如，毫克/目标组织)了解不多。 气雾剂的复杂性和吸入后的内部事件。加州大学欧文分校的空气污染健康影响实验室 自1974年医学院成立以来，一直从事这一领域的基础和应用研究。它已经发起了 关于吸入性气雾剂的若干专题多学科会议。此提案请求支持 国际会议：吸入气溶胶剂量学：进展、应用和对风险评估和 治疗学“，将在加州大学欧文分校的阿诺德和梅贝尔·贝克曼中心附近举行 科学院和工程院，在加利福尼亚州欧文，2024年10月3天。会议中心为您提供 支持包括有利于共事、包容和创造性思维的氛围。这次会议将给我们带来 科学家、工程师、医学研究人员、监管者和其他通常参加不同专业课程的人 会议，并在相对孤立的情况下阅读专业期刊，从而抑制跨学科交流和 合作。我们的组织委员会由10名男性和7名女性科学家组成，代表大学、政府和 私人实验室。他们意识到医学、科学和政府以及性别方面的关键研究需求 和种族不平等。会议内容包括：综述、最新研究、复杂混合物、体外方法以减少 活体动物的使用；计算机模型的进步；以及案例研究。每一次会议都是全体会议，旨在让 所有与会者，每个人都有讨论时间。该计划支持跨学科交流和协作。 注册费将包括所有会议以及附近机场(SNA)、酒店和机场之间的交通费用 会议中心。工作人员将帮助有特殊需要的人，并将努力吸引来自 代表不足的群体。学生们将与未来的雇主共进午餐，并将为 优秀的学生海报。将发表一篇论文集，并计划为符合条件的论文发行一期期刊 同行评议标准。创业支持由我校提供。总预算约为155,000美元，其中25,000美元是 要求NHLBI帮助支持工作人员和学生，并吸引代表不足的群体的与会者。 2022年11月26日修订

PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic exposed a critical lack of our understanding the airborne transmission of infectious viral agents. Deficiencies in understanding the deposition, metabolism, distribution in the body, and mechanisms of injury of aerosols (particles suspended in a gas) limit the confidence in setting air quality standards and developing new inhaled therapeutics. The delivered inhaled dose (e.g., mg/target tissues) is poorly understood due to individual differences, the complexity of aerosols, and post inhalation internal events. UC Irvine’s Air Pollution Health Effects Laboratory has been involved in basic and applied research in this area since its founding in the School of Medicine in 1974. It has initiated several topic-focused multi-disciplinary conferences on inhaled aerosols. This proposal requests support for an international conference “Inhaled Aerosol Dosimetry: Advances, Applications and Impacts on Risk Assessments and Therapeutics”, to be held adjacent to the UC Irvine campus at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, in Irvine, CA 3 days in October of 2024. The conference center offers solid support including an atmosphere conducive to collegiality, inclusion, and creative thinking. The conference will bring together scientists, engineers, medical researchers, regulators, and others who normally attend separate professional meetings, and read specialty journals in relative isolation thereby inhibiting cross-discipline communications and collaborations. Our Organizing Committee of 10 men and 7 women scientists represents universities, governments, and private laboratories. They are aware of critical research needs in medicine, science, and government, as well as gender and racial inequalities. Sessions include; overviews, recent research, complex mixtures; in-vitro methods to reduce the use of live animals; computer model advances; and case studies. Each session is plenary, geared to be understandable by all attendees, and each has discussion time. The program supports cross-discipline communication and collaboration. The registration fee will cover all sessions, and transportation between the nearby airport (SNA), the hotels, and the conference center. Staff will help those with special needs and efforts will be made to attract those from underrepresented groups. Students will have a luncheon with prospective employers, and awards will be made for outstanding student posters. A Proceedings will be published, and a journal issue is planned for those papers that meet peer review standards. Startup support is provided by our University. The total budget is about $155,000, and $25,000 is requested from the NHLBI to help support staff and students, and attract attendees from underrepresented groups. Revised 11-26-2022