Studies of Chemical Disposition in Animals

吸收，分布，代谢和消除开始在三种离子液体推广作为替代卤化溶剂在脱脂应用。正在进行口服和皮肤研究，以支持国家毒理学规划的亚慢性毒性研究。TBBPA和TBBPA- dbpe用作电路板和聚碳酸酯-丙烯腈-丁二烯-苯乙烯塑料的阻燃剂。工人普遍接触到这些化学物质，消费者也可能接触到。特别强调的是确定TBBPA-DBPE是否代谢产生2,3-二溴丙基醚，这是一种已知的动物致癌物。目前的研究还包括通过口服和皮肤途径研究离子液体的生物利用度。

Absorption, distribution, metabolism and elimination were begun on three ionic liquids that are promoted as replacements for halogenated solvents in degreasing applications. Oral and dermal studies are being conducted in support of the NTP sub-chronic toxicity studies. TBBPA and TBBPA-DBPE are used as flame retardents in circuit boards and polycarbonate-acrylonitrile-butadiene-styrene plastics. There is widespread worker exposure to these chemicals and possible consumer exposure. Special emphasis is being made to determine if TBBPA-DBPE is metabolized to produce 2,3-dibromopropyl ether, a known animal carcinogen. Present studies also include bioavailability studies of ionic liquids by the oral and dermal routes. Keywords Metabolite identification; NMR; HPLC; Mass spectrometry; Absorption; Distribution; Elimination; Kinetics; LSC; In vivo; In vitro; Radiolabeled compounds; Dermal; Gavage; IV; Inhalation; Mass balance; Ionic liquids; tetrabromobisphenol A; tetrabromobisphenol A-2,3 dibromopropyl ether; ionic liquids