Non-Clinical ADME Studies

该项目包括非临床吸收、分布、代谢、消除（ADME）研究，以支持NIDA的药物开发计划。该合同的非临床ADME研究通常包括体外和体内代谢研究，以及新药的毒性动力学。此外，该合同还涉及分析服务，包括通过质谱或核磁共振（NMR）对主要代谢物进行结构鉴定，以及使用高效液相色谱法（HPLC）、液相色谱-质谱法（LC-MS）、液相色谱-串联质谱法（LC/MS/MS/ MS）等方法对生物基质中的药物及其代谢物进行敏感和特异性分析。气相色谱-质谱分析（GC-MS）。

The project consists of nonclinical absorption, distribution, metabolism, elimination (ADME) studies to support NIDA's medications development program. The nonclinical ADME studies for this contract typically include in vitro and in vivo metabolism studies, and toxicokinetics of new medications. In addition, this contract also involves analytical services which include structure identification of major metabolites by mass spectrometry or nuclear magnetic resonance (NMR), and the development of sensitive and specific assays for a drug and its metabolites in biological matrices using methods such as high performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), liquid chromatography with tandem mass spectrometry (LC/MS/MS/, gas chromatography-mass spectrometry (GC-MS).