Inverse Geometry CT for Dose-efficient Volumetric Imaging

说明(由申请人提供)：通知编号：(NOT-OD-09-058)通知标题：NIH宣布恢复法案资金可用于竞争性修订应用项目摘要该项目的长期目标是开发一种全新的计算机断层扫描(CT)系统设计，承诺提供卓越的剂量效率和减少患者剂量，提高空间和时间分辨率，并在一次快速旋转中实现无伪影的大体积覆盖。其基本概念是逆几何CT(IGCT)，它采用一组X射线源，而不是传统CT系统使用的单一X射线源。该方法承诺在一次快速扫描中覆盖体积，而不会出现替代技术所面临的“锥形射束伪影”。此外，对于类似的图像质量，该方法可能导致患者剂量的显著减少。母公司R01赠款的主要目标是开发有史以来第一个基于门架的IGCT系统。由于资源的限制，目前的计划是第一次实施有一个由8个源组成的源模块。这一竞争性修订应用程序的目标是构建3个额外的源模块，使总数达到32个源。此次修订将为建造和整合额外来源的材料和劳动力提供资金，该住房已经设计为可容纳4个模块。改进后的源阵列的详细评估和测试将使用来自父赠款的资源进行。这一范围的扩大将使我们能够研究虚拟蝴蝶结，并在更接近最终临床环境的条件下测试IGCT的性能。 公共卫生相关性：逆向几何CT能够在没有锥束伪影的情况下进行器官旋转成像，具有提高空间和时间分辨率的潜力，并提供了一种显著减少获得所需临床信息所需的辐射暴露的方法。从历史上看，CT性能的改进总是带来重要的新应用，最大限度地减少CT扫描的辐射剂量是一个显著的好处，特别是在儿童和其他受电离辐射影响风险较高的群体中。这一竞争性修订将加快这项前景看好的技术的开发和评估。

DESCRIPTION (provided by applicant): Notice Number: (NOT-OD-09-058) Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications Project Summary The long term goal of this project is to develop a radically new Computed Tomography (CT) system design that promises to provide superior dose-efficiency and decreased patient dose, improved spatial and temporal resolution, and artifact-free wide volume coverage in a single fast rotation. The underlying concept, Inverse Geometry CT (IGCT), employs an array of x-ray sources in contrast to the single x-ray source used by conventional CT systems. The approach promises volumetric coverage in a single fast scan without "cone beam artifacts" that alternative techniques face. In addition, for comparable image quality, the approach could lead to significant reductions in patient dose. The main goal of the parent R01 grant is to develop the first ever, gantry-based IGCT system. Because of resource limitations, the current plan is for this first implementation to have one source module comprised of 8 sources. The aim of this competitive revision application is to build 3 additional source modules, bringing the total to 32 sources. The revision will fund the materials and labor for construction and integration of the additional sources into a housing that was already designed to accommodate 4 modules. The detailed evaluation and testing of the improved source array will be conducted using resources from the parent grant. This scope enhancement will allow us to study the virtual bowtie and to test the performance of IGCT under conditions closer to those of eventual clinical settings. PUBLIC HEALTH RELEVANCE: Inverse Geometry CT is capable of organ-in-rotation imaging without cone-beam artifacts, has the potential for improved spatial and temporal resolution, and offers an approach to significantly reduce the radiation exposure needed to obtain the required clinical information. Historically, improvements in CT performance have always led to important new applications, and minimizing the radiation dose of CT scanning is a significant benefit, especially in children and other groups at higher risk from the effects of ionizing radiation. This competitive revision will accelerate the development and evaluation of this promising technology.