Acquisition of a 500 MHz NMR Spectrometer for the University of Southern Calif

描述（由申请人提供）：南加州大学的化学和生物分子研究界目前由18个NIH拨款资助，正在申请获得500 MHz核磁共振光谱仪的拨款支持。这种仪器是迫切需要取代老化的仪器，这阻碍了我们的NIH资助的研究活动的进展。此次收购将大大扩展核磁共振波谱的可用性，以当前的研究项目在我们的大学公园校园，并支持生物医学为重点的化学研究的持续增长。该分光仪将支持许多具有很强的生物医学相关性和对人类健康有明显重大影响的项目。这些研究范围从新化学反应性的基础研究到药物发现、酶的结构和功能，以及纳米级医学诊断。我们的主要用户涉及三个主要领域的研究：DNA聚合酶保真机制（Goodman, McKenna, Prakash），作为分子探针的肽适体（Thompson, Roberts），以及新的合成方法和基于小分子的药物发现（Jung, Prakash, Williams, McKenna, Petasis）。这些研究项目正在合成方法学、复杂分子合成、药物发现、分子探针开发、生物化学、医学诊断和纳米技术等领域产生高影响力、变革性创新。这些程序都需要最先进的核磁共振仪器。所要求的仪器将对化学、生物和制药科学部门的所有科学研究产生直接和持久的影响，并促进高水平的本科生、研究生和博士后科学家的培训和教育。公共健康相关性：核磁共振波谱是阐明分子结构的主要工具，我们的核磁共振设施老化的基础设施限制了18个美国国立卫生研究院资助的研究项目在我们校园的进展。所要求的光谱仪将使小分子候选药物的结构分析、新化学方法的催化剂和分子探针的水平超出我们目前的能力。它也将成为研究小分子-蛋白质相互作用和优化用于医疗诊断的新型纳米设备的关键分析工具。

DESCRIPTION (provided by applicant): The chemical and biomolecular research community of the University of Southern California, currently funded by eighteen NIH grants, is requesting a grant support for the acquisition of a 500 MHz NMR spectrometer. This instrument is badly needed to replace aging instrumentation, which hampers the progress of our NIH- sponsored research activities. This purchase will significantly extend the availability of NMR spectroscopy to current research projects at our University Park campus and support ongoing growth of biomedical-focused chemical research. The spectrometer will support many projects that have strong biomedical relevance and clearly significant impact on human health. These range from basic research on new chemical reactivity to drug discovery, enzyme structure and function, and nanoscale medical diagnostics. Our major users are involved in research in three general areas: DNA polymerase fidelity mechanisms (Goodman, McKenna, Prakash), peptide aptamers as molecular probes (Thompson, Roberts), and new synthetic methods and small molecule-based drug discovery (Jung, Prakash, Williams, McKenna, Petasis). These research projects are producing high impact, transformative innovations in areas of synthetic methodology, complex molecule synthesis, drug discovery, development of molecular probes, biochemistry, medical diagnostics, and nanotechnology. Each of these programs requires state of the art NMR instrumentation. The requested instrument will have an immediate and lasting impact on all science conducted in the chemistry, biology, and pharmaceutical sciences departments and facilitates the training and education of undergraduate, graduate, and postdoctoral scientists at a high level. PUBLIC HEALTH RELEVANCE: NMR spectroscopy is a primary tool for the elucidation of molecular structure, and the aging infrastructure of our NMR facility is limiting the progress of eighteen NIH-sponsored research programs on our campus. The requested spectrometer will enable structural analysis of small molecule drug candidates, catalysts for new chemical methodology, and molecular probes at a level beyond our current capabilities. It will also be a key analytical tool for studying small molecule-protein interactions and optimizing new nano devices for medical diagnostics.