Acquisition of a Triple Quadrupole Mass Spectrometer

描述(由申请人提供)：伊利诺伊大学香槟分校(UIUC)罗伊·J·卡弗生物技术中心(CBC)寻求资金，以获得一台液体色谱/三重四极杆质谱仪(LC/QQQ MS)，以支持NIH资助的代谢组学中心的研究。我们NIH赞助的校园研究人员需要，但目前缺乏最先进的LC/QQQ质谱仪，用于代谢物分离、鉴定，特别是灵敏的定量。具体地说，应用生物系统公司的离子陷阱/QQQ混合系统4000 QTRAP具有电喷雾电离(ESI)、大气压化学电离(APCI)和大气压光电离(APPI)源，非常适合支持我们的代谢物研究需求。目前，代谢组学中心提供了LC/离子陷阱MS，但不足以支持对小分子的痕量定量分析。没有类似于所要求的仪器的仪器可供UIUC的NIH社区使用。因此，所要求的LC/QQQ MS对于正在进行的和正在出现的NIH赞助的项目是必不可少的。公共卫生相关性：伊利诺伊大学厄巴纳-香槟分校赞助的研究需要LC/三重四极杆质谱仪的小分子检测灵敏度和量化能力。我们有一个活跃的生物医学研究社区，其项目缺乏获得此类能力的机会。此次收购将支持高影响力的项目，包括神经递质表征、抗生素发现、营养和癌症研究。

DESCRIPTION (provided by applicant): The Roy J. Carver Biotechnology Center (CBC) of the University of Illinois at Urbana-Champaign (UIUC) seeks funding to acquire a liquid chromatography/triple quadrupole mass spectrometer (LC/QQQ MS) to support NIH funded research in our Metabolomics Center. Our on-campus NIH sponsored researchers require, but currently lack, access to state-of-the-art LC/QQQ Mass Spectrometry instrumentation for metabolite separation, identification, and especially, sensitive quantitation. Specifically, an Applied Biosystems hybrid ion trap/QQQ system, the 4000 QTRAP, with electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) sources, is ideally suited to support our metabolite research needs. Currently, an LC/ion trap MS is available in the Metabolomics Center, but does not adequately support trace quantitative analysis of small molecules. There is no instrumentation similar to the requested instrument available for use by the NIH community at UIUC. The requested LC/QQQ MS is thus essential for ongoing and emerging NIH sponsored projects. PUBLIC HEALTH RELEVANCE: The University of Illinois at Urbana-Champaign NIH sponsored research requires small molecule detection sensitivity and quantification capabilities of an LC/Triple Quadrupole mass spectrometer. We have an active biomedical research community whose projects lack access to such capabilities. This acquisition will support high impact projects, including neurotransmitter characterization, antibiotic discovery, nutrition, and cancer research.