Computational Shared Resource for Computational Biology

描述（由申请人提供）：医学研究的重点不断变化，生物医学更加强调数学、计算和统计方法。这些努力在很大程度上依赖于高性能计算和现代强大的计算资源。西奈山医学院的几个研究小组积极从事计算研究，已经建立了一个研究人员联盟（COI），以开发一种高性能的计算设备，该设备将由COI成员共享，并将满足他们的需求。COI认为计算设施由以下几个要素组成：1)一个现代化的、多用途的计算机集群，能够满足其成员的不同需求。2)为软件共享和开发提供高质量技术支持的环境。3)将服务于该机构的教育和培训计划的设施；4)根据美国国立卫生研究院描述的路线图发展和培育跨学科研究合作的环境。这份修订后的申请是为了获得最近宣布的共享仪器拨款计划（PAR-08-036）的支持，用于购买计算机集群并实现COI的目标之一。该联盟由一组美国国立卫生研究院支持的从事计算研究的研究人员组成。他们的研究领域包括：生物信息学和结构预测、计算神经科学、计算和理论生物物理学、数据库构建和信息检索、图像分析和模式识别、系统生物学和信号通路的数学建模、计算结构生物学和化学信息学。西奈山医学院已经认识到计算和数学生物医学在实现其在转化医学研究中的卓越潜力方面的重要性。为了支持这些努力，它建立了一个计算生物学共享资源设施（CB-SRF），该设施目前基于Apple G5集群，仅提供COI成员的部分计算需求。CB-SRF是机构图书馆学术计算单元的一部分，由该提案的PI Roman Osman和图书馆馆长Lynn Kasner-Morgan共同领导。CB-SRF的计算机集群已达到其有效功能寿命，很快将需要更换。因此，这一请求是及时的，对于建立对西奈山医学院正在进行的计算研究的持续支持具有重要意义。

DESCRIPTION (provided by applicant): The changing focus of medical research has introduced a greater emphasis on mathematical, computational and statistical approaches to biomedicine. These efforts strongly depend on high performance computing and modern powerful computational resources. Several research groups at Mount Sinai School of Medicine, actively engaged in computational research have established a Consortium of Investigators (COI) to develop a high performance computational facility that will be shared by the members of the COI and will fulfill their needs. The COI views the computational facility as composed from several elements: 1) A modern, multipurpose computer cluster that will be able to satisfy the diverse needs of its members. 2) An environment that will provide high quality technical support for software sharing and development. 3) A facility that will serve the educational and training programs of the institution and 4) A setting for developing and nurturing interdisciplinary research collaborations along the lines of the Roadmap described by the NIH. This revised application is to obtain support through the recently announced Shared Instrumentation Grant Program (PAR-08-036) for the purchase of the computer cluster and fulfilling one of the goals of the COI. The consortium comprises a group of NIH-supported investigators engaged in computational research. Their research fields include (among others): bioinformatics and structure prediction, computational neuroscience, computational and theoretical biophysics, data base construction and information retrieval, image analysis and pattern recognition, systems biology and mathematical modeling of signaling pathways, computational structural biology and cheminformatics. Mount Sinai School of Medicine has recognized the importance of computational and mathematical biomedicine in achieving its potential for excellence in translational medical research. To support such efforts it established a Computational Biology Shared Resource Facility (CB-SRF), which is currently based on an Apple G5 cluster that provides only a portion of the computational needs of the members of the COI. The CB-SRF is part of the Academic Computing unit in the institutional library and is co-directed by Roman Osman, the PI of this proposal and the director of the Library, Lynn Kasner-Morgan. The computer cluster of the CB-SRF is reaching the end of its effective functional life span and will soon require a replacement. Thus, this request is timely and of major importance for establishing continuing support to the ongoing computational research at Mount Sinai School of Medicine. PUBLIC HEALTH RELEVANCE: This revised application is to obtain support through the recently announced Shared Instrumentation Grant Program (PAR-08-036) for the purchase of the computer cluster and fulfilling one the research goals of the Consortium of Investigators. The current computer facility is reaching the end of its effective functional life span and will soon require a replacement. Thus, this request is timely and of major importance for establishing continuing support to the ongoing computational research at Mount Sinai School of Medicine