ACQUISITION OF THE INVEON SMALL ANIMAL PET/CT SYSTEM

描述(由申请人提供)：本建议书旨在从高端仪器项目中获得资金，用于从西门子临床前解决方案公司获得小动物PET和CT组合相机Inveon的资金。这款相机具有超过10%的灵敏度，12厘米的扩展视场，允许对全身动物(小鼠和大鼠)进行成像，并且大多数情况下，具有生成CT到PET图像的固有能力。解剖配准到功能图像现在是开发针对疾病的PET探针的先决条件，该探针使用肿瘤学、神经学、心脏病学、免疫学和肺科学等领域的动物模型进行研究。Mallinckrodt放射研究所参与了许多研究项目，其中很大一部分是由NIH拨款支持的，这意味着有广泛的研究人员参与。这种相机将允许开发用于研究活体人类疾病动物模型的显像剂。我们的大部分应用与癌症诊断和治疗的显像剂的开发有关。 公共卫生相关性：多模式成像现在代表心脏状态，用于开发致力于使用动物模型研究人类疾病的显像剂。使用动物模型很重要，因为它可以更快地验证假设。因此，它允许更快地验证用于诊断和治疗的显像剂，并使基础研究更快地转化为临床研究。

DESCRIPTION (provided by applicant): This proposal aims at acquiring funds from this High End Instrumentation Program for the acquisition of the small animal PET and CT combined camera, the Inveon from Siemens Pre- Clinical Solutions. This camera possesses a sensitivity of more than 10%, an extended field of view of 12cm allowing for imaging whole-body animals (mice and rats), and mostly, has inherent capability produce registered CT to PET images. Anatomical registration to functional image is now a prerequisite for the development of PET probes targeting the study of diseases using animal models in fields such as oncology, neurology, cardiology, immunology and pulmonary sciences. The Mallinckrodt Institute of Radiology is involved in numerous research projects, in the vast part supported by NIH grants, by the implication of a wide array of researchers. This camera will allow the developments of imaging agents for the study animal models of human diseases in vivo. Most of our applications are related to the developments of imaging agents for the diagnostics and therapy of cancer. PUBLIC HEALTH RELEVANCE: Multimodality imaging now represents the state of the heart for the development of imaging agents dedicated to the study of human diseases using animal models. Using animal models is important as it allow verification of hypothesis more quickly. It thus allow for faster validation of imaging agents for diagnostic and therapy and enables faster translation of basic research to clinical studies.