PA-06-555 Senior Scientist Research and Mentorship Award (K05)

描述（由申请人提供）：这一竞争性更新反映了我长期的研究和职业目标，即研究成瘾治疗，产生改善结果的信息，减轻成瘾对他人的负担，扩大国际成瘾研究，并指导年轻的研究人员从事成瘾研究事业。为此，我一直是抗抑郁药物治疗，丙氧芬维持，美沙酮维持及其对艾滋病毒风险和感染的影响，LAAM，丁丙诺啡，心理治疗，艾滋病毒疫苗，快速艾滋病毒检测，巴西和俄罗斯的艾滋病毒和药物使用，纳曲酮治疗海洛因成瘾并降低俄罗斯和美国的艾滋病毒风险，美沙酮患者不停止使用阿片类药物，动机激励，动机增强，以及其他临床试验网络（CTN）特拉华谷节点的私家侦探。我是NIDA研究部门，FDA药物滥用咨询委员会，DSM-IV药物滥用工作组，CPDD董事会和美国精神病学协会成瘾精神病学委员会的成员。我指导年轻的研究人员，为许多期刊审阅论文，担任两本杂志的副主编，监督住院医生，参与医学生教学，并共同指导费城退伍军人中心的成瘾部分，直到2004年从退伍军人中心退休。未来5年的研究活动包括发表丁丙诺啡对青少年/年轻人阿片类药物依赖个体的研究结果，这是之前K奖的重点，完成我们小组目前参与的CTN研究，开展CTN对初级保健中药物滥用干预的影响的综合研究，完成俄罗斯圣彼得堡的纳曲酮植入研究和基辅的美沙酮研究。提交R01研究纳曲酮植入与口服纳曲酮对圣彼得堡艾滋病毒阳性海洛因成瘾者抗逆转录病毒药物依从性的影响，在格鲁吉亚共和国开展一项每周三次的Suboxone治疗Subutex成瘾的研究，在巴西开展一项Concerta研究，以降低患有ADHD和大麻滥用或依赖的青少年感染艾滋病毒的风险，帮助制定俄罗斯成瘾和艾滋病毒治疗结合的指导方针。就初级保健中的美沙酮维持研究和植入丁丙诺啡研究进行咨询，并开展一项研究，以评估向出狱的阿片类药物依赖者提供治疗的影响。目前的学员有两名VA/NIDA研究员，一名来自马来西亚的INVEST研究员和一名来自第比利斯的学员。教育活动包括监督宾夕法尼亚大学的住院医生，领导宾夕法尼亚大学和退伍军人事务部的病例会议，参加医学院学生的成瘾课程，并与国际合作者合作研究课题，包括研究设计，实施，质量保证程序，人类受试者保护，撰写论文，促进良好的临床实践。

DESCRIPTION (provided by applicant): This competing renewal reflects my long-term research and career objectives to study addiction treatment, generate information that improves outcome and reduces the burden of addiction on others, expand international addiction research, and mentor young investigators for addiction research careers. To this end, I have been PI or a Co-l on studies on antidepressant pharmacotherapy, propoxyphene maintenance, methadone maintenance and its impact on HIV risk and infection, LAAM, buprenorphine, psychotherapy, a HIV vaccine, a rapid HIV test, HIV and drug use in Brazil and Russia, naltrexone for treating heroin addiction and reducing HIV risk in Russia and the U.S., methadone patients who do not stop opioid use, motivational incentives, motivational enhancement, and others as P.I. of the Delaware Valley Node of the Clinical Trials Network (CTN). I have been a member of NIDA study sections, the FDA Drug Abuse Advisory Committee, the DSM-IV Substance Abuse Work Group, CPDD Board of Directors, and the Board of Addiction Psychiatry for the American Psychiatric Association. I mentor young investigators, review papers for many journals, am associate editor of two, supervise residents, participate in medical student teaching, and co-directed the addictions component of the Philadelphia VA Center of Excellence until retiring from the VA in 2004. Research activities for the next 5 years include publishing results of the buprenorphine study of adolescent/young adult opioid dependent individuals that was a focus of the prior K award, finishing CTN studies in which our group is currently participating, developing CTN studies on the impact of integrating substance abuse interventions in primary care, completing a naltrexone implant study in St. Petersburg Russia and a methadone study Kiev, submitting a R01 to study the impact of naltrexone implant vs. oral naltrexone on adherence to antiretroviral medication in HIV+ heroin addicts in St. Petersburg, developing a study of thrice weekly Suboxone for Subutex addiction in the Republic of Georgia, and a study of Concerta for reducing HIV risk in adolescents with ADHD and marijuana abuse or dependence in Brazil, helping develop guidelines for integrating addiction and HIV treatment in Russia, consulting on a study of methadone maintenance in primary care and a study of implant buprenorphine, and developing a study to assess the impact of offering treatment to opioid dependent persons being released from prison. Current mentees are two VA/NIDA fellows, an INVEST fellow from Malaysia, and a mentee from Tbilisi. Educational activities include supervising a Penn resident, leading case conferences at Penn and the VA, participating in an addiction course for medical students, and working with international collaborators on research topics including study design, implementation, procedures for quality assurance, human subjects protection, writing papers, and facilitating Good Clinical Practice.