Administration

项目总结（见说明）：核心A 行政核心负责方案的运作和监督方案的实施。 提议的赠款。该核心促进了调查人员之间的沟通和外部调查人员的访问 MD安德森癌症中心核心维护临床和翻译的中央数据库 研究项目中描述的，以及GMP -免疫评估核心（核心E）。核心 支持POI中方案要求的FDA IND提交和报告。核心管理 计划人员和预算的每个部分的赠款。核心负责编写报告 for the research研究projects项目and publicafions出版. CML小组每周多次举行与白血病、干细胞移植和 与此项目相关的实验室研究。我们讨论的设计，状态和结果的临床和 实验室研究、样本采集、参与临床研究的患者状态， 病理学、细胞遗传学、分子分析综述。这包括每周一次的CML POI计划会议， 涉及白血病、干细胞移植和细胞疗法（SCTCT）的更广泛会议， 分子病理学项目。 具体而言，行政核心要实现以下目标： 领导和监督项目的核心和研究项目。 召开所有必要的会议，包括外部科学咨询委员会会议， 定期安排研究者会议，并讨论所有临床试验， 程序. 为NCI准备继续资助申请，并遵守内部报告 要求. <$协调数据质量控制和质量保证，与生物统计学和其他 项目和核心。 监控和控制支出，维护预算信息。 跟踪和维护所有出版物的记录，包括摘要和手稿， 程序项目。

PROJECT SUMMARY (See instnjctions): Core A The administrative core is responsible for the operation of the program and supervision of the conduct ofthe proposed grant. The core facilitates communication between invesfigators and visits of outside investigators to MD Anderson Cancer Center. The core maintains the central databases for the clinical and translational research described in the projects as well as the GMP - Immune Assessment Core (Core E). The core supports the FDA IND submissions and reporting required for protocols in the POI. The core manages program personnel and budgets for each section ofthe grant. The core is responsible for preparing reports forthe research projects and publicafions. The CML group meets multiple times per week in meeting related to leukemias, stem cell transplantafion and specific laboratory research related to this program. We discuss the design, status and results of clinical and laboratory research, sample acquisition, status of patients participating on clinical research studies, pathology, cytogenefics, molecular analysis review. This includes a weekly CML POI program meetings and broader meefings involving the Leukemia, Stem Cell Transplant and CellularTherapy (SCTCT) and Molecular Pathology programs. Specifically, the Administrative Core has the following objectives to accomplish: ¿ Provide leadership to and oversight of the cores and research projects ofthe Program. ¿ Convene all necessary meetings, including meetings ofthe External Scienfific Advisory Board, regulariy scheduled meetings of the investigators, and discussion of all the clinical trials in the program. ¿ Prepare grant continuafion submissions for the NCI and to comply with internal reporting requirements. ¿ Coordinate data quality control and quality assurance in conjuncfion with the Biostatistics and other projects and cores. ¿ Monitor and control expenditures and maintain budget information. ¿ Track and maintain record of all publications, including abstracts and manuscripts, resulfing from the program project.