Statistic Database and Datasharing Core

该计划项目的数据库和统计核心设在人力资源部。 加州大学洛杉矶分校医学院的遗传学。该部门包括10岁的最高3层 遗传学研究中心在贡达大楼。它有一个“最先进的”完全联网的计算机设施 由程序员和网络管理人员通过人类科学部的生物信息学核心组成。 遗传学此外，加州大学洛杉矶分校人类遗传学系已经发展成为其优势之一， 大量的统计遗传学研究小组，专注于开发遗传分析软件， 部门其中包括康托博士、辛希默博士、霍瓦特·帕普博士和兰格博士。最近的一些 该研究组在关联分析和数量性状连锁分析方面的软件开发， 由项目在当前周期中产生的数据和研究问题驱动。 数据库和统计核心托管并维护程序项目的中央服务器。这些 包括位于安全设施中的专用数据库、Web和终端服务器， 冷却和电力。这些机器可以访问超过42 TB的存储容量。将数据备份 每天晚上增量备份到RAID磁盘阵列，然后每个周末完全备份到数字磁带库。 所有服务器都保持在操作系统和应用软件的当前补丁级别。这些 专用服务器是强大的机器，这是程序项目的数据大小和复杂性所需要的。所有 机器将是高度安全的，同时仍然允许轻松访问和最大限度的安全。方案项目 科学家们还可以访问由人类遗传学维护的40多个节点的计算集群 IT人员。这个计算集群有一个完整的遗传应用程序库，并随着 当前版本或所请求的任何新软件包。 用作终端服务器的机器是一台8路Xeon 3 GHz计算机，具有16 GB RAM。 使用标准的Windows远程桌面连接（RDC）软件。项目数据分析师将 能够从任何地方访问这台计算机与互联网连接，通过个性化的，密码 保护账户。为了获得最佳速度，所有数据分析都将在终端传感器上进行，而不是在 客户的电脑。此终端服务器和数据库服务器之间存在千兆位连接， 数据传输通过使用64位版本的Windows操作系统和应用软件， 数据分析师可以确保访问几乎全部16 GB的数据空间，以进行大规模数值计算 Drs. Cantor、Sinsheimer、Horvath、Papp和Lange在纽约设有办公室、数据分析和计算机实验室， 建筑物，沿着与博士Pajukanta，Lusis和Reue的实验室，所以关于设计和数据的讨论 分析是广泛的，经常发生。为便利数据管理和统计及 本核心使用的遗传分析、数据库以及统计和遗传分析程序包括： 定期更新。此外，公开可用的遗传分析程序被安装在网络上， 这些资料可通过万维网查阅。数据每天备份。为及时了解 随着计算机技术的发展，计算机系统的硬件和软件都得到了升级 定期在加州大学洛杉矶分校人类遗传学系生物信息学核心。

The Database and Statistics Core of this Program Project is housed within the Department of Human Genetics in the UCLA School of Medicine. The Department encompasses the top 3 floors of the 10 year old Genetics Research Center in the Gonda Building. It has a 'state of the art' fully networked computer facility staffed by programmers and network managers through the Bioinformatics Core of the Department of Human Genetics. In addition, the UCLA Department of Human Genetics has developed as one of its strengths a substantial statistical genetics research group, focused on developing genetic analysis software within the Department. It includes Drs. Cantor, Sinsheimer, Horvath Papp, and Lange. Some of the most recent software developments in association analysis and quantitative trait linkage analysis by this group were motivated by data and research questions generated by the Program Project in its current cycle. The Database and Statistics Core hosts, and maintains the central servers for the Program Project. These include dedicated Database, Web, and Terminal servers located in a secure facility with professional-grade cooling and power. These machines have access to over 42 TB of storage capacity. The data is backed up incrementally each night to a RAID disk array and then fully backed up each weekend to a digital tape library. All servers are maintained at the current patch level of the operating system and application software. These dedicated servers are powerful machines as is required by the Program Project's data size and complexity. All machines will be highly secure while still allowing for easy access and maximum uptime. The Program Project scientists will also have access to a computational cluster of over 40 nodes maintained by the Human Genetics IT staff. This computational cluster has a full library of genetic applications, and is continually updated with current versions or any new packages that are requested. The machine used as the Terminal Server is an eight-way Xeon 3 GHz computer with 16 GB of RAM. Using standard Windows Remote Desktop Connectivity (RDC) software. Program Project data analysts will be able to access this computer from anywhere with an Internet connection, through personalized, password protected accounts. For optimal speed, all data analysis will take place on the Terminal Sen/er, not on the client's computer. There is a gigabit connection between this Terminal Server and the Database Server for fast data transfer. By using 64-bit versions of the Windows operating systems and the application software, the data analysts are assured access to virtually the full 16 GB data space for large-scale numerical computations Drs. Cantor, Sinsheimer, Horvath, Papp and Lange have offices and data analysis and computer labs in the building, along with the labs of Drs Pajukanta, Lusis and Reue, so discussions regarding design and data analysis are extensive and occur often. To facilitate data management and the performance of statistical and genetic analyses, databases and statistical and genetic analysis programs that are used by this Core are updated regularly. Additionally, publicly available genetic analysis programs are installed on the network as they become available through the worfdwide web. Data are backed up daily. In order to keep abreast of current developments in computing technologies, the computer system's hardware and software are upgraded on a regular basis in the UCLA Human Genetics Department Bioinformatics Core.