Physiological Characteristics and Data Management

所需的动物管理，以及从胃运动功能的病理生理学的综合纵向研究中产生的大量数据需要相当大的组织。生理表征和数据管理核心C将提供支持综合纵向动物研究所需的基础设施。该基础设施的核心是一个数据库，即电子动物研究记录（EARR），专为本计划项目设计，将由核心C管理。EARR将在安全服务器上存储单个鼠标的数据。存储的数据将包括测量结果 以及Core C直接进行的分析，以及各项目生成的相关数据和Imaging Core B进行的图像数据集分析。图像数据集将存储在成像核心B中维护的服务器上，但可通过服务器之间的数据管道从EARR内进行搜索。所有数据将与个体动物的EARR相关。数据分析工具是专门为满足项目调查人员的需求而设计的，并将提供快速公开分享本申请中提议的研究结果所需的信息。由Core C和Imaging Core B开发的数据挖掘工具将允许 研究人员收集大量动物的数据，进行回顾性分析。该数据库将具有灵活性，以满足项目调查人员不断变化的需求。核心C的第二个功能是在小鼠中进行项目项目要求的胃排空试验。胃运动功能的单一试验的集中组织将有效利用所有项目所需的设备，使试验标准化并确保进行质量控制。 Core C还将通过培训和后备技术服务为项目的动物模型管理提供支持。总体而言，核心C的这些功能将有助于项目实现各自的研究目标。所有项目都统一在一个总体目标，即确定胃运动功能障碍的分子机制，这将导致测试新的治疗干预措施的临床试验。生理表征和数据管理核心C将有助于确保实现这一目标。

The animal management required for, and the vast amount of data generated from integrative longitudinal studies of the pathophysiology of gastric motor function necessitates considerable organization. The Physiological Characterization and Data Management Core C will provide the infrastructure required to support integrative longitudinal animal studies. Central to this infrastructure is a database, the Electronic Animal Research Record (EARR), designed specifically for this Program Project, that will be managed by Core C. EARR will store data for individual mice on secure servers. Stored data will include measurements and analyses directly made by Core C as well as relevant data generated from each Project and analysis of image datasets made by Imaging Core B. Image datasets will be stored on servers maintained in Imaging Core B but will be searchable from within EARR via a data pipeline between servers. All data will be relationally linked to an individual animal's EARR. Data analysis tools were designed specifically to meet the needs of Project investigators and will provide information required for rapid public sharing of the results of studies proposed in this application. Data mining tools developed by Core C and Imaging Core B will allow researchers to compile data from a vast number of animals to perform retrospective analyses. This database will be flexible to meet the evolving needs of the Project investigators. A second function of Core C will be to perform the gastric emptying assays in mice required by the Projects of the Program Project. The centralized organization of this single assay of gastric motor function will make efficient use of the equipment needed by all Projects, standardize the assay and ensure that quality controls are performed. Core C will also provide support for animal model management to the Projects through training and back-up technical service. Collectively, these functions of Core C will facilitate the Projects to reach their respective research aims. All Projects are united in the overall objective to identify molecular mechanisms of gastric motor dysfunction that will lead to clinical trials that test novel therapeutic interventions. The Physiological Characterization and Data Management Core C will help to make sure this objective is reached.