Protein Structure and Function

描述（由申请人提供）：本提案请求支持继续发展堪萨斯大学卓越生物医学研究中心的蛋白质结构和功能（COBRE-PSF）。我们的中心成立于2002年10月，包括来自另外三所堪萨斯大学的参与者。五年后，我们的所有最初目标都已实现，而且在大多数情况下远远超过了目标。我们已让9名初级研究员毕业，获得独立的R01支持，并通过替代和试点项目拨款，额外招募和支持了15名初级研究员，举办了6次科学研讨会和3次拨款撰写研讨会，并激发了多项研究合作。我们还改造了6000多平方米。英尺的空间，新建了17,500平方英尺。成立了一个专门研究生物核磁共振的新核心，并制定了将COBRE-PSF转变为一个自给自足的研究中心的计划。我们的研究人员发表了超过226篇同行评审的手稿，并获得了69项研究资助，总额超过2200万美元。

DESCRIPTION (provided by applicant): This proposal requests support to continue development of a Center of Biomedical Research Excellence in Protein Structure and Function (COBRE-PSF) at the University of Kansas. Our Center was established in October 2002, and includes participants from three additional Kansas Universities. After five years all of our initial goals have been met and, in most cases, surpassed by a wide margin. We have graduated nine junior investigators to independent R01 support, recruited and supported a total of 15 additional junior investigators through replacement and pilot project grants, held six scientific and three grant-writing workshops, and inspired multiple research collaborations. We also remodeled over 6000 sq. feet of space, built a new 17,500 sq. foot Structural Biology Center, inaugurated a new Core dedicated to Bio-NMR, and enacted plans to move COBRE-PSF toward a self-sustaining research center. Our investigators have published over 226 peer-reviewed manuscripts and have received 69 research grants totaling more than $22 million. For the renewal period, our overall Aims for the Center are: 1. To recruit, mentor, and accelerate the career development of outstanding junior scientists 2. To enhance the capabilities of our existing Protein Production Core Laboratory (Core B) 3. To enhance the capabilities of our existing Protein Structure Laboratory (Core C) 4. To build a Bio-NMR Core Laboratory dedicated to Protein NMR studies (Core D) 5. To accelerate the professional and scientific growth of all Center participants through a combination of research meetings, seminars, grant application writing workshops, and scientific workshops. Our long-term goal is to attain a critical mass of successful, independent but collaborative investigators, focused on protein structure and function in health and disease, through which COBRE-PSF will become a self-sustaining enterprise into the future. Lay statement: Great advances in genomics paved the way for identifying the cellular proteins that are ultimately responsible for normal cell functioning and for the dysfunction underlying disease states. Development of therapeutic interventions begins with understanding the proteins involved in diseases, and this requires scientists with outstanding expertise in the study of cellular proteins.