TUSM/T-NEMC CENTER FOR NEUROSCIENCE RESEARCH

描述（由申请人提供）：本申请要求继续支持塔夫茨神经科学研究中心（CNR），这是一个由nads资助的中心，为塔夫茨神经科学社区提供研究核心服务。我们的社区由塔夫茨大学及其附属医院的14个部门的40个神经科学研究实验室组成。这些教师的兴趣涵盖了广泛的医学相关神经科学研究领域，包括突触生物学，离子通道功能，感觉和行为神经生物学，神经信号，神经可塑性和神经疾病。目前，在塔夫茨大学的神经科学家中有9个nind资助的项目，总共有44个NIH拨款（今年的直接费用为950万美元）。这些神经科学项目中的大多数严重依赖于nind资助的CNR提供的核心服务。CNR核心对塔夫茨大学的神经科学研究产生了重大影响。超过一半的塔夫茨神经科学研究实验室使用CNR核心设施，在过去的三年半里，在核心进行的研究至少发表了90篇论文，其中许多都是塔夫茨研究人员的合作研究。以下四个国家核资源中心目前全部或部分由新发展基金提供支助：(1)成像和细胞分析（荧光显微镜，共聚焦和双光子显微镜，激光捕获显微解剖，电子显微镜），(2)计算基因组学（基因微阵列，Q-PCR，生物信息学和计算生物学服务），(3)动物行为学（啮齿动物行为测试服务），(4)电生理学和生物物理学（单细胞记录，组织切片现场记录和组织切片单细胞记录）。我们核心的主要持续目标是为NINDS研究者，其他神经科学家和塔夫茨社区的其他研究者提供必要的研究服务。其次，CNR继续努力促进塔夫茨神经科学家之间的合作研究企业，并提供有利于整个塔夫茨神经科学界的培训和教育经验。神经科学是最近完成的塔夫茨医学院战略计划的主要组成部分，因此我们准备在不久的将来招聘新的神经科学家。在即将到来的大学神经科学的扩张中，我们相信CNR核心提供的负担得起的研究服务将大大增加为新聘用的塔夫茨神经科学家提供的启动包，并加快他们融入当地神经科学界。认识到CNR在塔夫茨神经科学研究项目中的重要作用，塔夫茨大学在最初阶段提供了重要的制度支持，以帮助建立核心设施-总计近100万美元的资金和翻新空间。重要的是，这种支持将在下一个拨款周期中继续（见部分B3），并极大地促进为塔夫茨神经科学家提供核心研究服务的努力。

DESCRIPTION (provided by applicant): This application requests continuing support for the Tufts Center for Neuroscience Research (CNR), a NINDS-funded center that provides research core services for the Tufts neuroscience community. Our community consists of 40 neuroscience research laboratories in 14 Departments of Tufts University and its affiliated hospitals. Interests among these faculty span a wide range of medically-relevant neuroscience research areas, including synapse biology, ion channel function, sensory & behavioral neurobiology, neural signaling, neural plasticity, and neurological disease. Presently, there are 9 NINDS-funded projects among Tufts neuroscientists and a total of 44 NIH grants (> $9.5 Million in direct costs this year). The majority of these neuroscience projects depend heavily on core services that are provided by the NINDS-funded CNR. The CNR Cores have had significant impact on neuroscience research at Tufts. More than half of the Tufts neuroscience research labs use CNR core facilities, and research conducted in the cores during the last 3.5 years has resulted in at least 90 publications, many of them describing collaborative studies by Tufts investigators. The following four CNR cores are now wholly or partially supported by NINDS funds: (1) Imaging & Cell Analysis (fluorescence microscopy, confocal & 2-photon microscopy, laser capture microdissection, electron microscopy), (2) Computational Genomics (gene microarrays, Q-PCR, bioinformatics and computational biology services), (3) Animal Behavior (rodent behavior testing services), and (4) Electrophysiology & Biophysics (single cell recording, tissue-slice field recording and tissue-slice single-cell recording). The primary continuing goal of our cores is to provide essential research services to NINDS investigators, other neuroscientists and other investigators of the Tufts community. Secondarily, the CNR continues to try to foster collaborative research enterprises among Tufts neuroscientists and to provide training and educational experiences that benefit the entire Tufts neuroscience community. Neuroscience is a major component of the recently completed Tufts Medical School strategic plan and thus we are poised to recruit new neuroscientists in the near future. During the coming expansion of neuroscience at the University, we believe that the affordable research services provided by CNR cores will greatly augment the start-up packages provided to newly-hired Tufts neuroscientists and speed their integration into the local neuroscience community. In recognition of the essential role that the CNR plays in the neuroscience research programs at Tufts, the University has provided significant institutional support to help establish the Core Facilities over this initial period- amounting to nearly $1,000,000 in funds and renovated space Importantly, such support will continue during the next grant cycle (see Section B3) and greatly facilitate the effort to provide core research services to Tufts neuroscientists.