Research Outcomes Accelerating Discoveries for Medical Applications and Practice

描述(由申请人提供)：作为太平洋盆地内从事生物医学和生物行为研究的美国主要高等教育机构，夏威夷大学马诺阿分校(UHM)寻求国家研究资源中心(National Center For Research Resources)下属的少数族裔机构研究中心(RCMI)计划的持续支持，通过建立旨在连接基础科学和临床医学的跨学科转化研究管道(TRIP)，在社区参与下改进患者护理实践，以进一步发展生物医学和健康方面的研究成果。指定研究成果加速医学应用和实践的发现(路线图)，2006-2011年周期的UHM RCMI计划将秉承NIH路线图的精神和原则，利用临床和翻译科学的新兴技术创建跨学科协作研究网络。具体地说，拟议的生物医学成像和生物工程及生物活性营养素研究活动，以及热带传染病检测和预防以及生物统计学和计算机支助服务的核心设施，将在很大程度上依赖于基础科学家和临床医生之间的密切跨学科合作和智力交流，应用人类生物学知识和物理学、数学、生理学、生物化学、分子生物学和微生物学的基本原理，为具有区域和国家重要性的健康差距制定新的和改进的针对疾病的诊断测试、治疗干预措施和预防战略。此外，这些活动将密切配合RCMI临床研究中心(RCRII)的基础科学、临床和以患者为中心的活动，以及其他由NCRR资助的倡议的活动，包括太平洋早期人类发展研究中心(CCRE)、太平洋新发传染病研究中心(COBRE)、免疫和神经疾病的细胞基础(INBRE)以及基因、细胞和系统水平上的情绪和认知(SNRP)。基础科学、临床医学和社区参与的三角测量也将有助于UHM更好地定位，全面参与RCMI翻译研究网络(RTRN)，并最终获得临床和翻译科学奖(CTSA)。已经为每一项研究和与研究有关的活动确定了强有力的领导。五名有前途的基础科学初级教员已经与临床科学家配对，进行高度创新、假设驱动、跨学科的转化性研究项目，这些项目很有可能导致独立资助。最后，正在开发和扩大补充技术核心，以便在争取国家卫生研究院用于研究和培训的主流外部资金方面取得更大成功。

DESCRIPTION (provided by applicant): As the principal U.S. institution of higher education engaged in biomedical and bio-behavioral research within the Pacific basin, the University of Hawaii at Manoa (UHM) seeks continued support from the Research Centers in Minority Institutions (RCMI) Program, of the National Center for Research Resources, to further develop research excellence in biomedicine and health by establishing a translational research interdisciplinary pipeline (TRIP) aimed at linking basic sciences and clinical medicine, integrating research discoveries with innovative medical applications, and developing improved patient-care practices with community participation. Designated Research Outcomes Accelerating Discoveries for Medical Applications and Practice (ROADMAP), the UHM RCMI Program for the 2006-2011 cycle will embrace the spirit and tenets of the NIH Roadmap by creating interdisciplinary collaborative research networks employing emerging technologies for clinical and translational sciences. Specifically, the proposed research activities on biomedical imaging and bioengineering and bioactive nutrients, as well as the core facilities for tropical infectious diseases detection and prevention and for biostatistics and computer support services, will rely heavily on close interdisciplinary collaborations and intellectual exchange between basic scientists and clinicians, in applying knowledge of human biology and fundamental principles of physics, mathematics, physiology, biochemistry, molecular biology and microbiology to develop novel and improved disease-specific diagnostic tests, therapeutic interventions and preventive strategies for health disparities of regional and national importance. Moreover, these activities will be designed to closely complement the basic science, clinical and patient-oriented activities of the RCMI Clinical Research Center (RCRII) and those of other NCRR-funded initiatives, including the Pacific Research Center for Early Human Development (CCRE), Pacific Center for Emerging Infectious Diseases Research (COBRE), Cellular Basis of Immunological and Neurological Disease (INBRE), and Emotion and Cognition on Gene, Cell and Systems Levels (SNRP). The triangulation of basic science, clinical medicine and community participation will also serve to better position UHM to participate fully in the RCMI Translational Research Network (RTRN) and to ultimately secure a Clinical and Translational Sciences Award (CTSA). Strong leadership has been identified for each of the research and research-related activities. And five promising basic-science junior faculty have been paired with clinician scientists to conduct highly innovative, hypothesis-driven, interdisciplinary translational research projects that have a high likelihood of leading to independent funding. Finally, complementary technical cores are being developed and expanded to achieve greater success in competing for mainstream extramural NIH funding for research and training.