Southwestern Comprehensive Sickle Cell Center

描述（由申请人提供）：西南综合镰状细胞中心（“中心”）是2003-2008年nhlbi资助的十个中心之一，正在申请下一个资助周期的持续支持。该中心位于达拉斯的德克萨斯大学西南医学中心（UT Southwestern）和达拉斯儿童医学中心（CMCD），将继续包括其他合作医疗中心，其医生和其他人员致力于镰状细胞病患者的护理，并开展新的临床、转化和卫生服务研究。其他这些中心是德克萨斯大学达拉斯分校、俄克拉荷马大学健康科学中心、德克萨斯大学加尔维斯顿分校和佛罗里达大学医学院。在CSCC临床试验联盟的当前资助期内，该中心的记录堪称典范。到目前为止，中心的研究人员领导了五个国家临床试验中的两个，并在联盟委员会中发挥着重要作用。此外，我们中心多个地点的临床试验入组人数也相当可观。目前在全国10个综合中心中患者入组排名第二。该中心还成功地执行了基础科学、中心内临床和各种其他合作和机构研究协议，并伴有顺利运作的行政和患者服务核心。该中心计划在未来五年内继续并显著扩大无数的研究、病人护理、教育和宣传活动。中心研究人员和他们的机构之间存在着一种凝聚力、互动性和协作精神，从而确保了西南综合镰状细胞中心的持续成功。

DESCRIPTION (provided by applicant): The Southwestern Comprehensive Sickle Cell Center (the "Center"), which has served as one of the ten NHLBI-funded Centers during 2003-2008 grant cycle, is applying for continued support during the next funding cycle. The Center, based at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) and Children's Medical Center Dallas (CMCD), will continue to include other collaborating medical centers whose physicians and other personnel are dedicated to the care of persons with sickle cell disease and the conduct of novel clinical, translational, and health services research. These other Centers are the University of Texas at Dallas, the University of Oklahoma Health Sciences Center, the University of Texas Medical Branch at Galveston, and the University of Florida College of Medicine. The Center's track record during the current grant period in the CSCC Clinical Trials Consortium has been exemplary. Center investigators lead two of the five national clinical trials opened thus far and play prominent roles on Consortium committees. Moreover, clinical trial enrollment from the multiple sites in our Center has been substantial. The Center currently ranks second overall among the ten comprehensive centers in patient enrollment. The Center is also successfully executing basic science, clinical intra-Center, and a variety of other collaborative and institutional research protocols, accompanied by smoothly functioning administrative and patient services cores. The Center plans to continue and appreciably expand myriad research, patient care, education, and advocacy initiatives during the next five years. A cohesive, interactive, and collaborative spirit exists among Center investigators and their institutions, thus assuring the Southwestern Comprehensive Sickle Cell Center's continued success.