Pharmacokinetics (Florida)

DMPK核心 DMPK核心提供支持新化学品发现的技术和能力 实体，范围从体外ADMET试验到大鼠和小鼠体内药代动力学。体外测定 包括对细胞渗透性、蛋白结合、代谢稳定性和药物-药物相互作用倾向的测量。 位于佛罗里达斯克里普斯的DMPK小组目前占地约1000平方英尺的实验室和办公室 位于佛罗里达朱庇特的一个41,000平方英尺的研究设施中。动物服务以一种新的状态提供- 最先进的设施约5,000平方英尺，可容纳约1500只小鼠， 240个鼠笼。动物园包括动物检疫和啮齿动物饲养室，专用程序 空间，以及一个生物安全3级（BSL 3）密封套，生物安全柜， 通风架和直通式高压灭菌器。动物服务由训练有素的工作人员提供， 合同兽医

DMPK CORE The DMPK core provides enabling technologies and capabilities to support the discovery of new chemical entities, ranging from in vitro ADMET assays to in vivo pharmacokinetics in rats and mice. In vitro assays include measures for cell permeability, protein binding, metabolic stability, and drug-drug interaction liabilities. The DMPK group at Scripps Florida currently occupies approximately 1000 sq/ft of laboratory and the office space housed in a 41,000 sq/ft research facility in Jupiter, Florida. Animal services are provided in a new stateof- the-art facility of approximately 5,000 square feet with the capacity to house approximately 1500 mouse and 240 rat cages. The Vivarium includes animal quarantine and holding rooms for rodents, dedicated procedure space, and a biosafety level 3 (BSL3) containment suite with shower-in requirement, biosafety cabinets, ventilated racks, and pass-through autoclave. Animal services are provided by a fully trained staff with a contract veterinarian.