Classification and Epidemiology of Emotional Disorders

描述（由申请人提供）：这份修改后的申请指导研究科学家发展奖（K01）概述了一个5年的培训计划，将为候选人的独立研究生涯做好准备，重点研究情绪障碍及其合并症。候选人的职业目标是研究情绪和焦虑障碍彼此之间以及与正常情绪之间的潜在界限，并利用这些知识来加强情绪障碍的分类和评估。然而，虽然候选人在焦虑症和Meehl的分类方法方面有很强的背景，但她需要在4个额外领域的技能来实现她的长期目标：(1)熟练掌握分类研究的统计技术，而不是分类方法；(2)深入了解心境障碍；(3)理解症状数据以外的变量（即神经生物学、人格、遗传），这些变量对情绪障碍的分类很重要；(4)具有精神病学的经验，该领域传统上是用来完善分类学系统的。这些知识缺口将通过以下方式解决：(1)统计学、情绪障碍、神经生物学、人格和遗传流行病学方面的教学培训；(2)情绪障碍及其合并症的临床培训；(3)通过对两项旨在为ICD-11和DSM-V的修订提供信息的主要调查进行研究实习，培训精神病学流行病学知识；(4)指导的研究项目的实施。该研究项目将整合结构和流行病学研究的方法，目的是(i)描述流行病学样本中6种常见的情绪和焦虑障碍的完整潜在结构，（ii）评估基于潜在结构信息修改诊断标准和阈值的流行病学后果，（iii）检查纯粹和共病情绪障碍的流行病学相关性，使用有关其潜在结构的信息进行分类。该项目有望为R01提案的发展提供信息，以支持对情绪焦虑共病的进一步研究，并完善候选人在该领域进行富有成效的独立研究的能力。预计该项目还将产生与公共卫生相当相关的成果，有可能导致更有效和有用的诊断评估，更好地发现需要服务的个人，以及更有效地预防和治疗情感痛苦。

DESCRIPTION (provided by applicant): This revised application for a Mentored Research Scientist Development Award (K01) outlines a 5-year training plan that will prepare the candidate for an independent research career focusing on the study of emotional disorders and their comorbidity. The candidate's career goal is to investigate the latent boundaries that separate the mood and anxiety disorders from one another and from normal emotions and to use this knowledge to enhance the classification and assessment of emotional disturbance. However, while the candidate has a strong background in the anxiety disorders and in Meehl's taxometric method, she requires skills in 4 additional areas to achieve her long-term goals: (1) proficiency in the statistical techniques of classification research beyond the taxometric method; (2) in-depth knowledge of the mood disorders; (3) understanding of variables beyond symptom data (i.e., neurobiological, personality, genetic) that are important for the classification of emotional disorders; and (4) experience with psychiatric epidemiology, the field traditionally enlisted to refine nosological systems. These gaps in knowledge will be addressed by: (1) didactic training in statistics, mood disorders, neurobiology, personality, and genetic epidemiology; (2) clinical training in emotional disorders and their comorbidity; (3) training in psychiatric epidemiology through research apprenticeships on two major surveys designed to inform revisions for ICD-11 and DSM-V; and (4) the conduct of a mentored research project. The research project will integrate the methods of structural and epidemiological research with the aims of (i) delineating the full latent structure of 6 commonly co-occurring mood and anxiety disorders in epidemiological samples, (ii) evaluating the epidemiological consequences of modifying diagnostic criteria and thresholds based on information about latent structure, and (iii) examining epidemiological correlates of pure and comorbid emotional disorders classified using information about their latent structure. This project is expected to inform the development of an R01 proposal to support further research into mood-anxiety comorbidity and to round out the candidate's ability to conduct productive, independent research in this area. The project is also expected to yield results with considerable relevance for public health, with the potential to lead to more valid and useful diagnostic assessments, better detection of individuals in need of services, and more effective prevention and treatment of emotional suffering.