ALCOHOL, HIV INFECTION AND HOST DEFENSE

描述(由申请人提供)：这是路易斯安那州立大学健康科学中心(LSUHSC)ARC的续签申请。ARC是一个由来自LSUHSC、杜兰国家灵长类动物研究中心(TNPRC)、Alton Ochsner诊所基金会和泽维尔大学的科学家组成的多学科团队，泽维尔大学是一所历史上的黑人学院/大学，其广泛的重点是酒精对人类免疫缺陷病毒(HIV)感染和疾病进展的影响。 ARC建立在成熟和富有成效的研究科学家的坚实基础上，他们的目的是通过促进研究、培训和教育方面的卓越来推动酒精研究领域的发展。ARC促进了一个协调、综合和协同的环境，以促进最大限度的生产力和科学卓越。ARC是一个地区性和全国性的研究资源，致力于在调查酗酒对艾滋病毒感染者的健康后果方面发挥领导作用。我们相信，ARC现在处于有利地位，可以将我们的研究成果转化为医疗实践，成为一个全面的ARC。我们对综合中心的拨款建议包括以下内容：行政核心部分、动物核心部分、分子/细胞生物学实验室核心部分、四个研究部分(“酒精、SIV感染和宿主防御”、“酒精和感染对淋巴细胞线粒体死亡信号的影响”、“酒精和艾滋病毒感染：附加神经心理影响”、“酒精、IL-17和肺炎克雷伯氏菌”)和一个试点项目部分。该提案的优势包括我们的生产力、我们在一个具有重要临床意义的领域的高度互动性和多学科范围的研究、我们研究的新颖性和机械性，以及我们ARC的组织成熟度。

DESCRIPTION (provided by applicant): This is a renewal application for the ARC at the Louisiana State University Health Sciences Center (LSUHSC). The ARC is a multidisciplinary team of scientists from the LSUHSC, the Tulane National Primate Research Center (TNPRC), the Alton Ochsner Clinic Foundation, and Xavier University, a Historically Black College/University, whose broad focus is the effect of alcohol on human immunodeficiency virus (HIV) infection and disease progression. The ARC is built on a strong foundation of established and productive research scientists whose purpose is to advance the alcohol research field by promoting excellence in research, training, and education. The ARC fosters a coordinated, integrated and synergistic environment that facilitates maximal productivity and scientific excellence. The ARC is a regional and national research resource that strives to assume a leadership position in investigating the health consequences of alcohol abuse in the HIV infected population. We believe that the ARC is now well positioned to translate our research findings into health care practice and become a Comprehensive ARC. Our grant proposal for a Comprehensive Center consists of the following: Administrative Core Component, Animal Core Component, The Molecular/Cellular Biology Laboratory Core Component, four Research Components ("Alcohol, SIV Infection, and Host Defense", "Effects of Ethanol and Infection on Mitochondriai Death Signaling in Lymphocytes", "Alcohol and HIV Infection: Additive Neuropsychological Effects", "Alcohol, IL-17, and Klebsiella Pneumonia"), and a Pilot Project Component. The strengths of the proposal include our productivity, the highly interactive and multidisciplinary scope of our research in an area of great clinical significance, the novel and mechanistic nature of our investigations, and the organizational maturity of our ARC.