Diabetes Research & Training Center

该提案是对NIDDK RFA-DK-06-014的回应，题为“华盛顿大学糖尿病研究与培训中心(WU DRTC)”。总体目标是支持华盛顿大学医学院(WUMS)糖尿病研究人员共享的集中资源、设施和专业知识，促进发现导致疾病及其并发症的基本机制，并将这些信息转化为预防、治疗和治愈。目前在其资助的第30个年头，吴DRTC在糖尿病研究方面做出了重大贡献，这是一个令人自豪的历史。在2002年的资助期间，积极的势头继续保持--目前，新成员增加了65%，NIH为糖尿病相关研究提供的资金也有了类似的增长，一个充满活力的试点和可行性计划(PFP)，可归因于DRTC核心的出版物总数的显著生产力(872)，以及核心设施的重大变化，使其更好地响应用户的需求。在下一个资助周期中，我们计划继续发展，以便WU DRTC能够响应糖尿病研究社区不断变化的期望。我们特别敏感的是，需要证明我们的研究进展与社会需求的相关性，并将基本的实验室进展转化为改善糖尿病患者的护理。最值得注意的是与圣路易斯大学公共卫生学院(SLU-SPH)于2005年秋季启动的一项新的重大合作。这所公共卫生学院是密苏里州唯一一所这样的学校，它的资源，再加上威斯康星大学在基础和临床糖尿病研究方面的优势，提供了一个强有力的合作伙伴关系，有望继续在糖尿病的诊断、治疗和预防方面取得重大进展。总而言之，WU DRTC现在的定位是通过以下方式继续应对当前RFA的挑战：1)增加DRTC的用户基础，同时相应增加与糖尿病相关的研究资金；2)与SLU-SPH结成联盟，扩大翻译研究和社区推广；3)与WU CNRU发展更紧密的互动，共享核心资源和丰富活动；4)通过改善与心血管研究中心的互动，加强我们在糖尿病心血管疾病重要领域的存在；5)与临床和翻译科学研究所建立合作伙伴关系，显著增加我们成员进行人类研究的机会，和6)发展WUMS-Barnes犹太糖尿病中心，为我们社区的糖尿病患者提供最先进的护理。我们相信，这些新方向将导致1)个人研究人员利用使能技术的效率提高；2)旨在临床前开发潜在治疗策略的更大合作；以及3)将最初的发现更快地转化为治疗糖尿病和相关代谢和内分泌疾病的有用方法。这里提出的具体目标就是为了实现这些目标。

This proposal is in response to NIDDK RFA-DK-06-014 and is entitled "Washington University Diabetes Research and Training Center (WU DRTC)". The overall goal is to support centralized resources, facilities, and expertise shared by diabetes investigators at Washington University Medical School (WUMS), to promote the discovery of fundamental mechanisms leading to the disease and its complications, and to translate this information into prevention, treatments, and cures. Currently in its 30th year of funding, the WU DRTC has a proud history of major contributions to diabetes research. Positive momentum has continued during the funding period of 2002-present with a 65% increase in new members, a similar increase in NIH funding for diabetes-related research, a vibrant Pilot and Feasibility Program (PFP), significant productivity in terms of total number of publications attributable to the DRTC Cores (872), and substantial changes in the Core facilities to make them more responsive to the needs of the users. In the next funding cycle we plan to continue to evolve so that the WU DRTC is responsive to the changing expectations of the diabetes research community. We are particularly sensitive to the need to demonstrate the relevance of our research advances to the needs of society and to translate basic laboratory advances to improvements in the care of diabetics. Most notable is the development of a major new collaboration with St. Louis University School of Public Health (SLU-SPH) initiated in the fall of 2005. The resources of this School of Public Health, which is the only such school in Missouri, when coupled with the strengths at WUMS in basic and clinical diabetes research, provides a potent partnership that promises to be able to continue to make significant advances in diagnosis, treatment, and prevention of diabetes. In summary, the WU DRTC has now positioned itself to continue to meet the challenges of the current RFA by 1) increasing the DRTC user base along with a commensurate increase in diabetes-related research funding, 2) forming an alliance with SLU-SPH for expanding translational research and community outreach, 3) developing closer interaction with the WU CNRU for sharing of core resources and enrichment activities, 4) enhancing our presence in the important area of diabetic cardiovascular disease by improved interaction with the Center for Cardiovascular Research, 5) forming a partnership with the Institute of Clinical and Translational Sciences that will markedly enhance our members' opportunities to conduct human research, and 6) developing the WUMS-Barnes Jewish Diabetes Center, that provides state-of-the-art care of diabetic patients in our community. We believe that these new directions will result in 1) greater efficiency in utilizing enabling technologies by individual investigators; 2) greater collaboration aimed at preclinical development of potential therapeutic strategies; and, 3) faster translation of initial discoveries into useful treatments for diabetes and related metabolic and endocrine disorders. The specific aims proposed here are designed to accomplish these goals.