caHub

与NCI高知名度项目（如TCGA和卓越研究专业项目）的直接经验以及来自科学界的更广泛的投入表明，对高质量生物标本的需求是惊人的，尚未得到满足。为了满足这一需求，OBBR正在积极规划实施caHUB，这是一种独特的、集中的公共资源，其主要任务是确保为研究界提供充足和持续的高质量人类生物标本。简而言之，caHUB将获取并向研究界提供根据最高技术和道德标准收集的生物标本，提供生物标本参考样本，作为标本完整性和分子类型的基准，开展支持循证生物标本最佳实践的研究，并为整个研究企业的合作和信息交换创造机会。caHUB将通过获取生物标本来确保其库存的质量，这些生物标本是根据循证标准操作程序（SOPs）收集和处理的，附有全面的临床、分子和收集数据注释，并从接受高质量护理的患者处采购的。将与军事、社区和学术机构建立分包合同，收集生物标本和相关数据。通过一个符合癌症生物医学信息网格（caHUB）标准的公共网络，caHUB将向包括学术界、政府、私人基金会、生物技术和制药行业在内的广泛研究社区提供样本和数据，并使所有研究领域的研究人员之间能够开展新的合作，从而加快发现和创新的步伐。2008年10月，NCI要求为建立和后续管理专题工作组（wg）提供技术和业务支持服务，以制定caHUB的战略计划。上汽集团被要求组建、促进和管理六个专题工作组，这对制定caHUB的综合计划和愿景至关重要。到目前为止，上汽集团已经成功建立了管理工作组（AWG），计划建立8个AWG相关的亚组，并形成了正常组织获取工作组。信息学工作组的成立和用户组讲习班的规划也在进行中。下一个财政年度将以优先、分阶段的方式启动更多的工作组和子工作组。

Direct experience with high-profile NCI initiatives (e.g., TCGA and the Specialized Programs of Research Excellence) and broader input from the scientific community have indicated a striking, unmet need for high-quality biospecimens. In response to this need, the OBBR is actively planning for the implementation of caHUB, a unique, centralized, public resource, the primary mission of which is to ensure the adequate and continuous supply of high-quality human biospecimens for the research community. Briefly, caHUB will acquire and make available to the research community biospecimens that have been collected according to the highest technical and ethical standards, provide biospecimen reference samples that serve as benchmarks for specimen integrity and molecular type, conduct research that supports evidence-based biospecimen best practices, and create opportunities for collaboration and information exchange across the research enterprise. caHUB will ensure the quality of its inventory by acquiring biospecimens that have been collected and processed according to evidence-based standard operating procedures (SOPs), annotated with comprehensive clinical, molecular, and collection data, and procured from patients who received high-quality care. Subcontracts would be established with military, community, and academic institutions to collect biospecimens and associated data. Through a cancer Biomedical Informatics Grid (caHUB¿)-compliant public network, caHUB will make specimens and data available to a broad research community, including academia, government, private foundations, and biotechnology and pharmaceutical industries, and enable new collaborations among researchers in all areas of investigation, thereby accelerating the pace of discovery and innovation. In October 2008, NCI requested technical and operational support services for the establishment and subsequent management of thematic working groups (WGs) to develop a strategic plan for caHUB. SAIC-F was requested to form, facilitate and manage six thematic working groups (WGs), critical to develop a comprehensive plan and vision for caHUB. To date, SAIC-F has successfully established the Administration WG (AWG), planned for eight AWG related subgroups, and formed the Acquisition of Normal Tissues WG. Formation of the Informatics WG and planning for a User Group Workshop also are ongoing. Additional WGs and subgroups will be launched in a prioritized, phased manner in the next fiscal year. NCI and the SAIC-F project management team are collaborating in the development of the management strategy for caHUB. OBBR and SAIC-F management and staff, with the assistance of consultants and experts from a variety of disciplines (e.g.., WG members), are responsible for implementing the resource¿s strategic plan. To date, six thematic WGs have been identified for the caHUB efforts, some of which have been further divided into additional subgroups.