Establishment of Laboratory of Molecular Imaging and Nanomedicine

新成立的分子成像和纳米医学实验室的预期研究领域包括：1)分子成像探针开发——开发用于生物化学过程体内成像的分子成像探针，包括正电子发射断层扫描、光学成像（荧光和拉曼）、磁共振成像、对比度增强超声、光声和多模态成像。分子成像与解剖和功能成像相结合可以提高对疾病的认识，使早期发现成为可能，并加强对治疗反应和药物发现和开发的监测。方法包括化学合成，蛋白质工程，生物偶联，放射性标记，化学分析，临床前研究，以及使用各种体外和体内技术的临床翻译。2)纳米治疗学——水溶性、生物相容性纳米颗粒的合理设计，用于综合成像和治疗。由聚合物、金属、陶瓷和脂质等材料合成的纳米颗粒（<100nm）可以同时进行诊断成像、药物输送和治疗反应监测。方法包括合成、物理化学表征、表面修饰和生物偶联、药代动力学和药效学评价，以便转化为临床应用。

Examples of intended areas of research of the new Laboratory of Molecular Imaging and Nanomedicine include: 1) Molecular Imaging Probe Development--Developing molecular imaging probes for in vivo imaging of biochemical processes, including positron emission tomography, optical imaging (fluorescence and Raman), magnetic resonance imaging, contrast enhanced ultrasound, photoacoustic and multimodal imaging. Molecular imaging in combination with anatomic and functional imaging can improve understanding of disease, enable early detection, and enhance monitoring of therapeutic responses and drug discovery and development. Methods include chemical synthesis, protein engineering, bioconjugation, radiolabeling, chemical analysis, preclinical studies, and clinical translation using various in vitro and in vivo techniques. 2) Nano Theranostics--Rational design of water-soluble, biocompatible nanoparticles for combined imaging and therapy. Nanoparticles (<100nm) synthesized from materials such as polymers, metals, ceramics and lipids permit simultaneous diagnostic imaging, drug delivery, and monitoring of therapeutic responses. Methods include synthesis, physiochemical characterization, surface modification and bioconjugation, pharmacokinetic, and pharmacodynamic evaluation in rodents for translation to clinical application.