MECHANOELECTRIC FEEDBACK IN CARDIAC DEFIBRILLATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心脏颤动是心脏杂乱无章的电行为，其后果是协调肌肉的丧失。 收缩。通过及时对心脏施加强烈的电击来进行电除颤，长期以来一直被用作 对这种致命的心律失常的有效治疗。近年来，除颤治疗已经 由于其改进的可访问性和功能，它大大扩展了。尽管这项技术的关键作用是 在拯救人类生命中发挥作用，电击阻止危及生命的干扰的基本机制 人们对心脏节律的了解还不完全。 机械收缩伴随着心脏的电活动。然而，人们早就知道，有一种 电和机械过程之间的串扰，这可能在抗心律失常治疗中发挥作用。由于 心脏结构和行为的复杂性，机械作用以前从未被考虑过 心脏除颤机制的研究。这项研究的目标是确定 在心脏除颤过程中的机电反馈，从而增加我们对心脏除颤的认识 心脏暴露在强烈电击下终止纤颤的机制。此应用程序旨在 杜兰大学计算心脏电生理学小组与 国家生物医学计算资源，从而，充分利用最先进的结合 两组分别发展了心脏除颤和机械收缩的建模方法。 项目完成后，预计将使人们对复杂的机电设备的理解达到一个新的水平 心脏中的事件可用于抗心律失常治疗。作为NBCR的合作项目，本研究 将促进延展连续性及其解剖、电气和机械模型和 算法将允许与心脏和躯干的Bidomain模型更好地集成，从而开放给 在心脏起搏、休克和心电图中的一系列应用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiac fibrillation is disorganized electrical behavior of the heart, and its consequence is the loss of coordinated muscle contraction. Electrical defibrillation by timely application of a strong electric shock to the heart has long been used as an effective therapy for this otherwise lethal disturbance of cardiac rhythm. In recent years defibrillation therapy has dramatically expanded due to its improved accessibility and functionality. Despite the critical role that the technique plays in saving human life, the fundamental mechanisms by which electrical shocks halt life-threatening disturbances in cardiac rhythm are not completely understood. Mechanical contraction follows the electrical activation of the heart. However, it has long been known that there is a cross-talk between the electrical and mechanical processes which could play a role in anti-arrhythmia therapy. Owing to the complexities in cardiac structure and behavior, mechanical contributions have never before been considered in the investigation of cardiac defibrillation mechanisms. The objective of this research is to determine the contribution of mechanoelectrical feedback in the process of cardiac defibrillation, and thus, to increase our knowledge of the mechanisms by which the exposure of the heart to strong electric shocks terminates fibrillation. This application seeks to establish collaboration between the Computational Cardiac Electrophysiology Group at Tulane University and the National Biomedical Computation Resource and thus, to take full advantage of the combination of state-of-the-art approaches in modeling cardiac defibrillation and mechanical contraction, respectively, developed by the two groups. Upon completion, the project is expected to bring a new level of understanding to how the complex electro-mechanical events in the heart can be used to benefit anti-arrhythmia therapy. As a collaborative project of the NBCR this research will promote extensions to the development of Continuity and its anatomic, electrical and mechanical models and algorithms that will permit greater integration with bidomain models of the heart and torso, opening in up to the large array of applications in cardiac pacing, shock and electrocardiography.