Translational Therapy

翻译治疗核心的目的是提供最先进的翻译研究支持 为癌症中心计划成员提供服务，以促进新型细胞和免疫系统的发展 治疗：具体地说，核心与调查人员合作，以获取、选择和操纵 细胞产品在基础或临床前研究环境中，然后在大规模临床前验证运行中 导致它们在GMP工厂生产。CORE与调查人员合作开发和实施 免疫监测分析，以评估新的生物制剂和细胞为基础的疗法的影响 宿主免疫功能。利用已建立的软件和信息技术，核心可以帮助癌症 中心研究人员将临床结果与产品特性和宿主的任何变化相关联 免疫功能。例如，已经建立了标准化的监测技术来监测 肿瘤患者接受造血细胞移植、异基因NK细胞治疗后的免疫完整性 或者调节性T细胞输注、免疫佐剂和癌症特异性疫苗。核心还充当 从参与转化性研究的患者那里收集的血液和骨髓的储存库。

The purpose of the Translational Therapy Core is to provide state of the art translational research support services to Cancer Center program members to facilitate the development of novel cellular and irnmunebased therapies.: Specifically, the core collaborates with investigators to procure, select and manipulate cellular products in the basic or preclinical research setting and then in large-scale pre-clinical validation runs leading to their production in a GMP facility. The core Works with investigators to develop and implement immune monitoring assays to assess the impact of novel biological agents and cell-based therapeutics on host immune function. Using established software and information technologies, the core can assist Cancer Center investigators in correlating clinical outcomes with product characteristics and any alterations in host immune function. For example, standardized monitoring techniques have been established to monitor immune integrity in cancer patients after treatment with hematopoietic cell transplantation, allogeneic NK cell or regulatory T-cell infusions, immune adjuvants, and cancer specific vaccines. The core also serves as the repository for blood and marrow collected from patients participating in translational research studies.