Integrating EEG/MEG and fMRI: 99-M-0172

脑磁图数据记录和信号处理方法的发展已经非常成功。对工作记忆任务和听觉处理任务的研究已经显示了定位大脑激活和解决阶段性与紧张性活动问题的能力。我们也已经开始调查表型的措施，将适用于许多相关的研究，特别是同胞项目。我们现在正在学习几乎所有通过兄弟项目录取的科目。 认知激活过程中的脑磁图记录显示出与功能磁共振成像非常相似的定位能力。特别是皮质水平的β去磷酸化与BOLD激活结果一致。然而，MEG/EEG允许使用其他成像技术不可能的时间信息。跨大脑区域的相位关系已经使用先进的信号处理技术得到了证明。迄今为止，我们的研究结果表明，对大脑结构和功能的测量是发现易感基因的有力工具。 在工作记忆任务中，精神分裂症患者与健康的同胞和正常对照志愿者相比，其激活程度不同，特别是在额叶区域，这是由β去激活所指示的。对这种激活的进一步研究揭示了与已充分研究的COMT标记的基因型的相互作用。

Development of MEG data recording and signal processing methods has been very successful. Studies of working memory tasks and auditory processing tasks have shown the ability to localize brain activation and to address issues of phasic versus tonic activity. We have also begun to investigate phenotype measures that will be applicable in many related studies and specifically the sibling project. We are now studying almost all subjects admitted thru the sibling project. MEG recording during cognitive activation has shown the ability to localize in very comparable fashion to fMRI. Specifically beta desynchronization at the cortical level has been found to agree with BOLD activation results. However, the MEG/EEG allows for temporal information not possible with other imaging techniques. Phasic relationships across brain areas have been demonstrated using advanced signal processing techniques. Our results to date show that measures of brain structure and function represent powerful tools to find susceptibility genes. Diffrerences in the degree of activation especially in frontal regions as indexed by beta desynchronization during a working memory task have been found between patients with schizophrenia compared to well siblings and normal control volunteers. Further investigation of this activation has revealed an interaction with genotype for the well studied COMT marker.