T Cell responses in Liver Gene therapy
T Cell responses in Liver Gene therapy
批准号:
7595327
负责人:
James M Wilson
金额:
$40.86万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-07-01 至 2014-06-30
关键词:
AbetalipoproteinemiaAddressAdenovirusesAdoptive TransferAffinityAnimal ModelAnimalsAntigensCapsidCardiovascular DiseasesCell LineCellsClinicalClinical ResearchClinical TrialsComplementary DNACross PresentationCytotoxic T-LymphocytesDNA VirusesData AggregationDependovirusDiseaseEngineeringEngraftmentEpitopesEvaluationFamilial HypercholesterolemiaFamilyGaggingGene TransferGenerationsHIVHIV-1Health SciencesHemophilia AHepatocyteHepatotoxicityHumanHuman ResourcesImmuneImmunizationInfectionInjection of therapeutic agentLast NameLiverLow Density Lipoprotein ReceptorMHC Class I GenesMacacaMemoryModelingMusNamesOregonPennsylvaniaPopulationPrimatesPrincipal InvestigatorPrintingProcessProteinsRegistriesReporter GenesResearchResearch Project GrantsRoleSafetySeriesStem cellsT memory cellT-Cell ActivationT-LymphocyteT-Lymphocyte EpitopesTechnologyTimeToxic effectTransferaseTransgenesTriglyceridesUniversitiesWild Type MouseXenograft procedureadeno-associated viral vectorbasecellular engineeringgene therapyhuman embryonic stem cellliver xenograftmature animalmouse modelnonhuman primatenovelpre-clinicalpreclinical studyprogramsreconstitutionresearch studyresponsevector
中文摘要
根据需要使用续页,以下列格式提供所需信息。
从项目总监/主要研究者开始。按字母顺序列出所有其他高级/关键人员,姓氏在前。
名称eRA Commons用户名组织在项目中的角色
作者:James M. WILSONJM宾夕法尼亚大学PI
王丽丽LILIWANG宾夕法尼亚大学Co-Pi
其他重要贡献者
名称组织在项目中的角色
宾夕法尼亚大学合作者
Grompe,Marcus俄勒冈州健康与科学大学合作者
人胚胎干细胞的分类
如果拟开展的项目涉及人类胚胎干细胞,请在下面列出以下列表中特定细胞系的注册号:
http://stemcells.nih.gov/research/reaistrv/.根据需要使用续页。
如果此时无法引用特定的行,请包括一个声明,说明将使用注册表中的一行。
细胞系
PHS 398(2007年11月修订版)第t页,1表格第2页-续
请在以下各页上依次编号
应用程序.不要使用诸如4a,4 b,
项目I项目主任/首席研究员(最后,第一,中间):威尔逊,詹姆斯M。詹姆斯·威尔索
项目负责人/主要研究者的姓名必须在每个打印页和每个续页的顶部提供。
研究资助
目录
页码
说明,项目/
英文摘要
Use continuation pages as neededto provide the required information in the format shown below.
Start with Program Director(s)/Principal Investigator(s). List all other senior/key personnel in alphabetical order, last name first.
Name eRA Commons User Name Organization Role on Project
Wilson, James M. WILSONJM University of Pennsylvania PI
Wang, Lili LILIWANG University of Pennsylvania Co-Pi
OTHER SIGNIFICANT CONTRIBUTORS
Name Organization Role on Project
Riley, James University of Pennsylvania Collaborator
Grompe, Marcus Oregon Health & Science University Collaborator
Human Embryonic Stem Cells ^ No Q Yes
If the proposedproject Involves humanembryonic stem cells, list below the registration number of the specificcell line(s) from the following list:
http://stemcells.nih.gov/research/reaistrv/. Usecontinuation pages as needed.
If a specific line cannot be referenced at this time, include a statement that one from the Registry will be used.
Cell Line
PHS 398 (Rev. 11/07) Page t,1 Form Page 2-continued
Number the following pages consecutivelythroughout
the application. Do not use suffixes such as 4a, 4b,
PROJECT I Program Director/Principal Investigator (Last, First, Middle): Wilson, James M. / WilSOH, James M.
The name of the program director/principal investigator must be provided at the top of each printed page and each continuation page.
RESEARCH GRANT
TABLE OF CONTENTS
Page Numbers
Description, Project/
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
T CELL RESPONSES IN LIVER GENE THERAPY
-
批准号:8147961
-
项目类别:
-
资助金额:$43.27万
-
财政年份:2010
-
负责人:James M Wilson
-
依托单位:
Immune Barriers to AAV Gene Therapy
-
批准号:8151675
-
项目类别:
-
资助金额:$21.81万
-
财政年份:2010
-
负责人:James M Wilson
-
依托单位:
Regulated Transgene Expression in the Retina
-
批准号:7817814
-
项目类别:
-
资助金额:$49.46万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
Immune Barriers to AAV Gene Therapy
-
批准号:7802296
-
项目类别:
-
资助金额:$14.0万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
DNA virus as vectors for cardiovascular diseases
-
批准号:7822199
-
项目类别:
-
资助金额:$2.84万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
Administrative Core
-
批准号:7595335
-
项目类别:
-
资助金额:$11.61万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
Preclinical Studies of AAV Gene Therapy in MOuse Models of Urea Cycle Disorders
-
批准号:7802297
-
项目类别:
-
资助金额:$14.0万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
Administrative Core
-
批准号:7802302
-
项目类别:
-
资助金额:$14.0万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
Regulated Transgene Expression in the Retina
-
批准号:7945314
-
项目类别:
-
资助金额:$49.65万
-
财政年份:2009
-
负责人:James M Wilson
-
依托单位:
Gene Therapy for Urea Cycle Disorders
-
批准号:7596238
-
项目类别:
-
资助金额:$98.03万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Gene Therapy for Urea Cycle Disorders
-
批准号:7355751
-
项目类别:
-
资助金额:$98.55万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Immune Barriers to AAV Gene Therapy
-
批准号:7450485
-
项目类别:
-
资助金额:$12.29万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Preclinical Studies of AAV Gene Therapy in MOuse Models of Urea Cycle Disorders
-
批准号:7450493
-
项目类别:
-
资助金额:$12.29万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Administrative Core
-
批准号:7450510
-
项目类别:
-
资助金额:$12.29万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Gene Therapy for Urea Cycle Disorders
-
批准号:7943736
-
项目类别:
-
资助金额:$21.81万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Gene Therapy for Urea Cycle Disorders
-
批准号:7802304
-
项目类别:
-
资助金额:$99.83万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
Gene Therapy for Urea Cycle Disorders
-
批准号:8056524
-
项目类别:
-
资助金额:$119.83万
-
财政年份:2008
-
负责人:James M Wilson
-
依托单位:
NHLBI GTRP Preclinical Vector Production Core Laboratory
-
批准号:8065586
-
项目类别:
-
资助金额:$112.57万
-
财政年份:2007
-
负责人:James M Wilson
-
依托单位:
Pilot
-
批准号:7499954
-
项目类别:
-
资助金额:$5.47万
-
财政年份:2007
-
负责人:James M Wilson
-
依托单位:
Animal
-
批准号:7509244
-
项目类别:
-
资助金额:$26.07万
-
财政年份:2007
-
负责人:James M Wilson
-
依托单位:
海外基金