ANALYSIS OF 3D BREAST SURFACE DEFORMATION DURING MAMMOGRAPHIC COMPRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 刘凤山 乳房X线片压缩过程中乳房表面三维变形分析 乳房X光摄影是筛查无症状妇女早期乳腺癌的标准临床影像手段。乳房压迫是乳房X光检查的重要组成部分，会导致乳房亲属的畸形。当比较在不同时间拍摄的乳房图像或使用不同模式的图像时，考虑这种变形是很重要的。在本项目中，我们研究了乳房表面变形、表面力分布和施加的乳房X线片压缩力之间的关系，这对于设计一种改进的乳房定位方案是必要的，目的是在乳房X光检查中实现更舒适和更少的运动。本研究还可用于改进乳房X线片配准方法，改进乳腺组织建模和乳房X光照相模拟。 该项目的具体目标包括：1.开发乳房压缩分析系统；2.使用物理体模对压缩分析系统进行评估；3.在10-20名志愿者中进行乳房变形的初步临床研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fengshan Liu Analysis of 3D Breast Surface Deformation during Mammographic Compression Mammography is the standard clinical imaging modality for screening asymptomatic women for early breast cancer. Breast compression, which is an essential part of the mammographic exam, causes deformation of the breast relative. It is important to account for this deformation when comparing breast images taken at different times, or images using various modalities. In this project we study the relationship between the breast surface deformation, surface force distribution, and the applied mammographic compression force, which is necessary for designing an improved breast positioning protocol aimed at achieving more comfort and less motion during mammography. This study could also be used for improving mammogram registration methods, and for refinement of breast tissue modeling and mammography simulation. The specific aims of this project include: 1. Development of a breast compression analysis system; 2. Evaluation of the compression analysis system using physical phantoms; and 3. Pilot clinical study of breast deformation with 10-20 volunteers.