UNIVERSITY OF NEBRASKA AT OMAHA - BIOLOGY AND COMPUTER SCIENCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Uno Biology有三名INBRE合伙人，威廉·塔普里奇、伊莱恩·拉休和唐纳德·罗文。塔普里奇博士负责管理这笔赠款。Tapprich博士和Rowen博士是传染病主题的成员，Lahue博士是细胞信号主题的成员。所有同事都已向国际期刊提交了手稿，所有人的手稿都已被接受出版。塔普里奇博士有两份出版物，一份发表在微生物学和免疫学的当前主题上，另一份发表在《病毒学杂志》上。罗文博士有一篇发表在微生物学杂志上的论文。拉休博士有一份用酵母菌制成的出版物。所有的同事还在国内和国际会议上介绍他们的工作。 目前，联合国大学生物学领域有六位布林学者，他们是丹·雷默、扎克里·迈耶、乔尔·里瓦斯、卡拉·戈登、本·汉泽尔和梅根·纳尔逊。前四名将于2005年5月毕业。丹和扎克已经被UNMC医学院录取，乔尔还没有决定他未来的计划，卡拉在攻读博士学位之前将作为研究技术员工作一年。目前所有的学者都积极参加并在国内和国际会议上展示他们的研究工作。卡拉和扎克是院系杰出专业奖的获得者，卡拉作为联合国大学杰出本科生获得了今年的奖项。马库斯·芬奇、苔丝·艾德姆和莫娜·索鲁里三位新学者被选为来年的学者。所有人都将在UNMC开始暑期项目。 INBRE赠款提供的资金使我们能够在该部门建立DNA测序设施和定量实时聚合酶链式反应设施。INBRE赠款的供应和旅行资金对于维持我们的研究计划是非常宝贵的，并直接导致了将于今年出版的出版物。 联合国组织的计算机科学系继续在生物信息学领域取得重大发展。在新开发的生物信息学项目中，5名教员(包括4名INBRE同事)、10名研究生和20名本科生(包括5名布林学者)对生物信息学活动做出了贡献，生物信息学活动继续增长。 INBRE的四位同事(赫沙姆·阿里、陈正新、帕瓦蒂·春迪和马克·保利)一直非常积极地参与生物信息学领域的领先研究和教育活动。除了这四名同事外，另一名计算机科学教员郭黑峰也表现出了兴趣，并在该领域进行了研究。该小组的研究成果意义重大，在几次专业会议上发表了成果，并在三种期刊上发表，许多会议论文集被引用。他们一直在指导一些研究生，其中包括五名博士生。此外，开发了三门新的生物信息学课程，并在最后两个学期开设了这门课程。此外，一位新的生物信息学研究员刘国庆将于今年夏天加入联合国大学，接受计算机科学系和生物系的联合任命， 2004年的两位布林学者(Nicholas Palermo和Sarfraz Chandio)继续从事与去年夏天开展的项目有关的项目。在几次区域活动以及两次国际会议上介绍了项目的成果。今年夏天，这两位学者将继续在他们去年夏天加入的同一个研究实验室开展活动。三名新的布林学者从七名申请者中脱颖而出，将于今年夏天加入研究实验室。这三位学者都是联合国大学提供的生物信息学新学位的20名学生之一。这个新学位吸引了许多优秀的学生，预计在未来几年内将迅速增长。 计算机科学系继续拥有一个重要的计算设施，该设施是由前一轮布林拨款和NSF EPSCoR基础设施拨款开发的。集群计算设施满足生物信息学学生和教职员工的所有研究和教育需求。目前正在研究几种方案，以升级和维护这些设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UNO biology has three INBRE associates, William Tapprich, Elaine Lahue and Donald Rowen. Dr. Tapprich administers the grant. Drs. Tapprich and Rowen are members of the infectious disease theme and Dr. Lahue is a member of the cell signaling theme. All associates have submitted manuscripts to international journals and all have had their manuscripts accepted for publication. Dr. Tapprich has two publications in press, one in Current Topics in Microbiology and Immunology and one in Journal of Virology. Dr. Rowen has a publication accepted in Microbiology. Dr. Lahue has a publication accepted in Yeast. All of the associates are also presenting their work at national and international meetings. There are now six BRIN scholars in UNO biology, Dan Reimer, Zachary Meyer, Joel Rivas, Kara Gordon, Ben Hanzel, and Megan Nelson. The first four will be graduating in May 2005. Dan and Zach have been accepted into medical school at UNMC, Joel is still undecided about his future plans and Kara will work for a year as a research technician before pursuing a Ph.D. All of the current scholars have been active in attending and presenting their research work at national and international meetings. Kara and Zach were recipients of the departmental awards for outstanding major and Kara received this year's award as the outstanding undergraduate at UNO. Three new scholars have been selected for the coming year, Marcus Finch, Tess Eidem and Mona Sorouri. All will begin summer projects at UNMC. Funds made available from the INBRE grant enabled us to establish a DNA sequencing facility and a quantitative real time PCR facility in the department. Supply and travel funds from the INBRE grant are invaluable in maintaining our research programs and have led directly to the publications that will appear this year. The computer science department at UNO continues to develop significantly in the area of Bioinformatics. The Bioinformatics activities are continuing to grow with the contribution of five faculty members (including four INBRE associates), ten graduate students and twenty undergraduate students in the newly developed Bioinformatics programs (including five BRIN scholars). The four INBRE associates (Hesham Ali, Zhengxin Chen, Parvathi Chundi and Mark Pauley) have been very active in leading research and educational activities in Bioinformatics. In addition to the four associates, another computer science faculty member, Heifeng Guo, has shown interest and has conducted research in the field. The research output of the group has been significant, with results presented in several professional meetings and published in three journals and many referred conference proceedings. They have been supervising a number of graduate students including five doctoral students. Additionally, three new courses in Bioinformatics were developed and offered the last two semesters. Also, a new Bioinformatics researcher, Guoqing Liu, will be joining UNO this summer on a joint appointment between the departments of Computer Science and Biology, The two 2004 BRIN (Nicholas Palermo and Sarfraz Chandio) Scholars continued to work on projects related to the ones conducted last summer. The results of the projects were presented in several regional events as well as in two international conferences. This summer, both scholars will continue their activities at the same research labs they joined last summer. Three new BRIN Scholars were selected from seven applicants and will join research labs this coming summer. All three scholars are among the 20 students on the new degree in Bioinformatics offered at UNO. The new degree has been attracting many outstanding students and is expected to grow rapidly in the next couple of years. The computer science department continues to house a significant computational facility that was developed by funds from an earlier round of the BRIN grant and an NSF EPSCoR infrastructure grant. The cluster computing facility serves all research and educational needs of the Bioinformatics students and faculty. Several options are currently been investigated to upgrade and maintain the facilities.