Women's Health Initiative

妇女健康倡议(WHI)的目的是解决心血管疾病、乳腺癌、结肠癌/直肠癌和骨质疏松症，这些都是绝经后妇女死亡、残疾和生活质量下降的最常见原因。WHI的主要组成部分是：绝经后激素治疗(HT)、饮食调整(DM)和钙/维生素D补充(CAD)的随机对照临床试验；以及伴随的观察性研究(OS)。临床试验和观察性研究部分于2005年完成；WHI扩展研究继续跟踪所有同意的参与者的健康结果和选定的暴露。这一补充后续行动的目的是描述原始干预措施的长期影响，记录HTT试验参与者激素使用的变化，扩大WHI可以可靠解决的科学问题的范围，并提供能够支持额外研究的基础设施，这些研究需要绝经后妇女非常大型的纵向研究的一些独特资源。

The purpose of the Women's Health Initiative (WHI) is to address cardiovascular disease, cancers of the breast and colon/rectum, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The major components of the WHI are: a randomized controlled clinical trial of postmenopausal Hormone Therapy (HT), Dietary Modification (DM), and Calcium/Vitamin D supplementation (CaD); and a companion observational study (OS). The Clinical Trials and Observational Study components were completed in 2005; the WHI Extension Study continues to follow all consenting participants for health outcomes and selected exposures. The purpose of this additional follow-up is to describe the longer term effects of the original interventions, to document change in hormone use in participants from the HT trials, to expand the range of scientific questions that can be reliably addressed in the WHI, and to provide an infrastructure able to support additional investigations requiring some of the unique resources of a very large longitudinal study of postmenopausal women.