Addition and Expansion of Laboratory Animal Research Fa*

描述（由申请人提供）： 请求支持扩大福克斯大通癌症中心西楼现有的四层实验室动物设施（LAF），在现有设施上增加一个四层楼的侧翼。增加25，290总平方英尺将增加12，910净平方英尺的动物研究空间。超过6000平方英尺的空间用于空气处理设备，支持合并的新设施（旧设施加上拟议的增加）。这一增加，加上现有设施的翻新（计划于2006-2007年）和增加使用高密度微隔离笼（已经开始），将使研究小鼠的能力增加到25，600笼。按照我们目前和预期的使用率，这种扩展将满足FCCC研究人员的动物研究需求，直到2010年。 费城目前集中管理的AAALAC认证项目的能力已经被超越，现有的大部分设施过度拥挤，缺乏安全的微生物屏障，使研究面临因感染而无效的风险。拟议的增加将纠正动物空间的不足，并提供一个高质量的小鼠研究屏障设施，为在严格的微生物安全环境中扩大基因组服务提供空间。它紧邻现有设施，将能够利用中央笼清洗和支持服务。它还将为地下室的土拨鼠和鸭子区增加一个小的洗笼区，以更好地将它们与屏障鼠研究设施分开。这一扩展将提供： -2，032 nsf的检疫空间，用于对入境小鼠进行健康评估和重新分类。 -4，967个额外的老鼠收容室 -1，078 nsf新增程序实验室 - 额外的笼子清洗和程序区域，以支持土拨鼠和鸭病毒性肝炎研究 - 每个研究小鼠饲养区入口处的高压灭菌器、更衣和灭菌能力 除此之外，扩建还将为整个LAF的检疫设施和空气处理提供机械空间。园区目前过度开发，使得机械支持设备的可用空间至关重要。因此，冷却塔将位于屋顶上，并且对于支持LAF的冗余冷冻水容量是必要的。屋顶成为冷却塔的主要真实的地产，以支持这个快速增长的研究综合体。

DESCRIPTION (provided by applicant): Support is requested to expand the existing four-story Laboratory Animal Facility (LAF) in the West Building of the Fox Chase Cancer Center by adding a four-floor wing onto the current facility. This addition of 25,290 gross square feet will add 12,910 net square feet of animal research space. Over 6000 square feet of space is utilized for air handling equipment which supports the combined new facility (old facility plus the proposed addition). This addition, combined with renovation of the existing facility (planned for 2006-2007) and increased use of high density microisolator cages (already begun), will increase the research mouse capacity to 25,600 cages. At our current and expected rate of use this expansion will satisfy the animal research needs of research investigators at FCCC until 2010. Capabilities of the current centrally administered AAALAC accredited program in Philadelphia have been exceeded and much of the existing facility is overcrowded and lacks a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The proposed addition will correct deficiencies in animal space, and provide a high quality mouse research barrier facility with space for expanding genomic services in a setting of stringent microbiological security. Located immediately adjacent to the existing facility, it will be able to utilize central cagewashing and support services. It will also add a small cagewash area for the basement woodchuck and duck area to better separate them from the barrier mouse research facilities. This expansion will provide: -2,032 nsf of quarantine space for the health evaluation and rederivation of incoming mice. -4,967 nsf of additional mouse holding rooms -1,078 nsf of additional procedural laboratories -additional cage washing and procedural areas for support to woodchuck and duck viral hepatitus studies -autoclave, gowning and sterilization capability at the entry to each research mouse holding area In addition to the above, the expansion will house mechanical space for the quarantine facility and air handling for the entire LAF. The campus is currently overdeveloped making available space for mechanical support equipment critical. Therefore, cooling towers will be located on the roof and are necessary for redundant chilled water capacity supporting the LAF. Rooftops become prime real estate for cooling towers to support this rapidly growing research complex.