Infectious Triggers in Chronic Fatigue Syndrome

描述（由申请人提供）：慢性疲劳综合征（CFS）是一种病因不明的主要致残性疾病。它直接影响了400多万美国人。传染性病原体一直受到高度怀疑，但从未得到证实。他们发现的障碍是缺乏一种广泛的方法，既可以检测单个样品中多种微生物的存在，又可以检测微生物的新变种。这进一步受到阻碍，因为超过99%的微生物无法培养，可能无法检测到。与过去的局限性相比，我们将采用一种能够克服这些障碍的新方法。在CFS的脑脊液中发现潜在病原体将改变研究疾病的方法以及可能的早期检测，预防和治疗。这可能是产生新的假设和开始调查微生物的因果关系以及预防（鸡蛋疫苗）或抵消微生物病原体影响的途径。 公共卫生相关性：慢性疲劳综合症是成年人的主要后天性疾病。原因尚不清楚。如果我们能够发现一个疑似的传染病原因，就可以开发诊断和治疗方法，以减少个人的成本和痛苦，以及我们的医疗保健系统和经济的负担。

DESCRIPTION (provided by applicant): Chronic Fatigue Syndrome (CFS) is a major disabling illness of unknown etiology. It directly impacts more than four million Americans. Infectious agents have been highly suspected but none have ever been validated. Obstacles to their discovery have been lack of a broad approach that can both detect the presence of multiple microbes in a single sample and detect novel or variants of microbes. This has been further hampered because more than 99% of all microbes cannot be cultured and may go undetected. In contrast to past limitations, we will use a new approach that can surmount these obstacles. The discovery of potential pathogens in cerebrospinal fluid of CFS would be field-altering in terms of approach to the study of the disease and possible early detection, prevention and treatment. This could be the gateway step to generate new hypotheses and begin investigation into a microbe's causal association and ways to prevent (egg vaccine) or counteract the effects of a microbial pathogen. PUBLIC HEALTH RELEVANCE: Chronic Fatigue Syndrome is the major acquired disease of productive adults. The cause remains unknown. If we can uncover an infectious cause, which is suspected, diagnostics and therapies may be developed to decrease costs and suffering to the individual and the burden on our health care system and economy.