Rochester Epidemiology Project

描述(由申请人提供)：此续签申请请求支持罗彻斯特流行病学项目(REP)，该项目自1966年以来一直支持明尼苏达州奥姆斯特德县居民的病历链接系统。这一独特的研究基础设施记录了从20世纪初到现在为社区居民提供的医疗保健，并支持对几乎每项研究设计和发生在美国的大多数疾病实体进行基于人群的流行病学调查。该代表支持了梅奥医学中心、奥姆斯特德医学中心和其他学术机构的大量研究人员的工作，并使具有重大社会影响的疾病的外部资助研究得以高效进行。该代表目前支持40项由政府资助的赠款，自42年前首次资助以来，已在同行评议文献中发表了1800多篇手稿，其中包括自我们上次竞争续签是在2005年以来的214篇。这种来自地理上定义的人口的广泛数据存储库在这个国家几乎是无与伦比的，这一重要的研究基础设施被保留并扩展到未来是至关重要的。这笔赠款的每一个周期不仅提供了维持核心医疗记录联系功能的机会，而且还提供了加强其效用的机会。在这份续签申请中，我们提议在2015年前更新REP医疗记录链接系统(目标1)；通过连接有关医疗服务和程序及其相应费用、药物处方和免疫接种的更多数据来增强REP基础设施(目标2)；并将REP基础设施扩大到居住在明尼苏达州东南部8县地区(奥姆斯特德加上周围的道奇、菲尔莫、瓦巴沙、穆尔、古德休、威诺纳和休斯顿等县；目标3)的更多个人人口。这些新目标建立在我们当前和以前项目周期取得的成就的基础上，这些成就包括更及时地收集数据、对历史纸质医疗记录进行大规模扫描和建立诊断索引、增加新的信息来源和分析方法、开发正在进行的人口普查统计，以及开发工具以在提供更高的数据安全性的同时提高获取的便利性。因此，更新申请中提出的目标将为越来越多的临床研究人员、流行病学家、统计学家和基础科学家组成的多学科团队提供更多的数据，这些团队正在解决重大的公共卫生问题。最终目标是继续支持以人口为基础的疾病病因学研究、预防干预、改进医疗实践和改善人口健康，如NIH路线图中所概述的那样。公共卫生相关性：这一续签申请请求支持罗彻斯特流行病学项目(REP)，该项目自1966年以来一直支持明尼苏达州奥姆斯特德县居民的医疗记录联系系统。这一独特的研究基础设施记录了从20世纪初到现在为社区居民提供的医疗保健，并支持对几乎所有研究设计和发生在美国的大多数疾病实体进行基于人群的流行病学调查。最终目标是继续促进基于人群的疾病病因研究、预防干预措施、改进的医疗实践和更好的人口健康，如NIH路线图中所概述的那样。

DESCRIPTION (provided by applicant): This renewal application requests support for the Rochester Epidemiology Project (REP) that has supported the medical records-linkage system for residents of Olmsted County, MN, since 1966. This unique research infrastructure chronicles the medical care delivered to community residents from the early 1900s to the present and has supported population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in the U.S. The REP has supported the work of a large number of investigators at Mayo Medical Center, Olmsted Medical Center, and other academic institutions, and has permitted the efficient conduct of extramurally- funded studies of diseases with substantial societal impact. The REP currently supports 40 government-funded grants, and since its initial funding 42 years ago, more than 1,800 manuscripts have been published in the peer-reviewed literature, including 214 since our last competing renewal in 2005. This extensive data repository from a geographically-defined population is virtually unparalleled in this country, and it is essential that this important research infrastructure be preserved and extended into the future. Each cycle of this grant has presented an opportunity to not only maintain the core medical records-linkage function, but also to enhance its utility. In this renewal application, we propose to update the REP medical records-linkage system through 2015 (Aim 1); to enhance the REP infrastructure by linking additional data on medical services and procedures and their corresponding costs, drug prescriptions, and immunizations (Aim 2); and to expand the REP infrastructure to the larger population of individuals residing in the 8-county region of southeastern Minnesota (Olmsted plus surrounding Dodge, Fillmore, Wabasha, Mower, Goodhue, Winona, and Houston counties; Aim 3). These new aims build on our accomplishments from the current and previous project cycles that include more timely data collection, massive scanning and diagnostic indexing of historical paper medical records, addition of new sources of information and analytic methods, development of an ongoing census enumeration, and development of tools to increase ease of access while providing greater data security. Thus, the aims proposed in this renewal application will provide increased data availability for the growing number of multidisciplinary teams of clinical investigators, epidemiologists, statisticians, and basic scientists who are addressing significant public health questions. The ultimate goal is to continue to support population-based research of disease etiology, preventive interventions, improved medical practice, and better health for the population, as outlined in the NIH Roadmap. PUBLIC HEALTH RELEVANCE: This renewal application requests support for the Rochester Epidemiology Project (REP) that has supported the medical records-linkage system for residents of Olmsted County, MN, since 1966. This unique research infrastructure chronicles the medical care delivered to community residents from the early 1900s to the present and supports population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in the U.S. The ultimate goal is to continue to facilitate population-based research of disease etiology, preventive interventions, improved medical practice, and better health for the population, as outlined in the NIH Roadmap.