IGNITE Investigation to Guide New Insights for Translational Effectiveness

描述(由申请人提供)：本提案涉及挑战领域(15)：翻译科学和挑战主题15-NR-101*NIH研究伙伴计划：翻译研究的途径。我们将为太平洋西北部12个部门(约1200名消防员)的消防员确定有效传播、采用和使用既定的、以证据为基础的工作场所健康促进/减少伤害计划的方法。该计划是以研究为基础的，经过开发、研究以确定疗效，并通过Beta测试以达到NIH资助的规模。该提案建立在先前的工作和在消防设施方面的成就记录的基础上。这项研究设计是一项前瞻性的观察队列试验，旨在为有效的翻译定义一个层次模型，该模型将通过对每个翻译阶段的冥想分析来验证。基于理论的框架组件将使用现有的可靠仪器进行最佳测量，其中许多仪器来自调查人员之前的工作。通过使用额外的定性数据进行三角测量，将在这些复杂的环境中丰富研究结果。调查人员拥有现有的同事关系和独特的互补视角和技能，包括职业健康促进、组织心理学、高级统计能力和与消防员社区的牢固联系。消防服务提供了作为研究环境的优势：需要该计划的高风险群体，在动荡的经济中相对稳定，参与者招募/留存较高，数据收集容易，而且由于我们的社区合作，应用研究结果的界限清晰。该提案将提供已确定的工具变量和可在此环境和其他环境中验证和操纵的翻译路线图。进行这项试验将立即为研究地点社区带来经济利益，因为改善消防员的健康并减少因提前退休、加班、疾病和受伤而产生的成本将使这些资金重新用于其他社区需求。一旦制定了翻译路线图，将其广泛推广到全美3万个消防部门，每年将节省近10亿美元，并用于提供其他就业和服务。

DESCRIPTION (provided by applicant): This proposal addresses Challenge Area (15): Translational Sciences and the Challenge Topic 15-NR-101* NIH Partners in Research Program: Pathways for Translational Research. We will identify means to effectively disseminate, adopt and use an established, evidence-based worksite health promotion/injury reduction program for firefighters in 12 departments (~1200 total firefighters) in the Pacific NW. The program is research-based and was developed, studied to establish efficacy and beta tested to go to scale with NIH funding. The proposal builds on that prior work and a record of accomplishments in fire service settings. The study design is a prospective observational cohort trial to define a hierarchical model for effective translation, and that model will be validated with meditational analyses of each translational phase. The theory-based framework components will be measured optimally using existing reliable instruments, many drawn from investigators' prior work. Findings will be enriched in these complex environments by triangulating with additional qualitative data. Investigators have existing collegial ties and unique complimentary perspectives and skill sets, including occupational health promotion, organizational psychology, advanced statistical abilities and strong ties to the community of firefighters. The fire service offers advantages as a study setting: a high risk group in need of the program, relative stability in a turbulent economy, high participant recruitment/retention, ease of data collection, and because of our community partnering, clear lines to apply findings. The proposal will provide identified instrumental variables and a roadmap for translation that can be validated and manipulated in this and other settings. Conducting this trial will have immediate economic benefits for the study site communities, as improving the health of firefighters and reducing costs due to early retirement, overtime, illness and injury will allow those funds to be redirected toward other community needs. Once the roadmap for translation is established, extending it broadly to the 30,000 fire departments across the U.S. would allow almost $1 billion dollars a year to be saved and channeled into providing other jobs and services.