Epigenetic regulation of AEC Plasticity and epithelial-mesenchymal transition

描述（由申请人提供）：本提案的目的是招募一名新的独立研究者（NIl）到肺重症监护医学部（DPCCM）担任终身职位。该NIl将被纳入USC肺生物学中心（USC- clb）的协作环境，该中心是DPCCM的基础科学研究组成部分。USC-CLB的目标是通过促进研究和促进在一个支持性环境中的核心研究小组之间的相互作用，促进对肺部疾病致病机制的理解，这些研究小组专注于肺泡上皮细胞和分子生物学。USC-CLB的一个关键目标是吸引年轻的研究人员在肺细胞生物学和支持他们过渡到独立。为了实现这些目标，南加州大学clb提供了可供南加州大学clb研究人员使用的共享设备，并运营一个细胞培养核心，为研究人员提供研究试剂。南加州大学- clb促进与其他学科和部门的研究人员合作，这些研究人员有兴趣将他们的专业知识应用于肺生物学。所聘用的个人将在肺细胞和分子生物学方面有很强的背景和训练。基于与南加州大学clb核心研究主题的相关性，该研究员将重点研究肺泡上皮细胞分化和上皮间质转化的表观遗传调控，这将促进南加州大学clb与表观基因组中心的相互作用，并为南加州大学clb带来新的专业知识。NIl将可以使用南加州大学clb的所有共享设备以及南加州大学健康科学校区的所有核心。项目将由项目负责人和一个由南加州大学- clb成员组成的委员会以及合作调查人员指导，他们将通过定期评估生产力来密切监测项目的进展。NIl将与南加州大学- clb其他部门、中心和研究所的所有研究人员和具有特定相关专业知识的合作者进行互动。USC-CLB在DPCCM内将为NIl提供一个协作和智力支持的环境，以成功建立独立的研究生涯。该机构承诺在本P30提案所要求的供资期限之外再提供两年的支助。

DESCRIPTION (provided by applicant): The objective of this proposal is to recruit a newly independent investigator (NIl) to a tenure track position in the Division of Pulmonary Critical Care Medicine (DPCCM). The NIl will be incorporated into the collaborative environment of the USC Center for Lung Biology (USC-CLB), the basic science research component of DPCCM. Goals of the USC-CLB are to advance understanding of pathogenic mechanisms of pulmonary disease by facilitating research and promoting interactions in a supportive environment among a core group of investigators focused on cell and molecular biology of lung alveolar epithelium. A key objective of the USC-CLB is to attract young investigators in lung cell biology and to support their transition to independence. To promote these goals, the USC-CLB provides shared equipment that is available for use by USC-CLB investigators and operates a Cell Culture Core to provide investigators with research reagents. The USC-CLB fosters collaborations with investigators in other disciplines and departments who have an interest in applying their expertise to lung biology. The individual to be hired will have strong background and training in lung cell and molecular biology. Based on relevance to the core research themes of the USC-CLB, the NIl will focus his/her research on epigenetic regulation of alveolar epithelial cell differentiation and epithelial-mesenchymal transition, which will facilitate interactions between the USC-CLB and the Epigenome Center and bring new expertise to the USC-CLB. The NIl will have access to all shared equipment in the USC-CLB and to all cores on the USC Health Sciences Campus. The NIl will be mentored by the PI and a committee comprised of USC-CLB members as well as collaborating investigators who will closely monitor progress of the Nil through regular assessments of productivity. The NIl will interact with all USC-CLB investigators and collaborators with specific relevant expertise in other departments, centers and institutes. The USC-CLB within DPCCM will provide a collaborative and intellectually supportive environment for the NIl to successfully establish an independent research career. The institution is committed to providing two additional years of support beyond the period of funding requested in this P30 proposal. Studies to be performed by the newly independent investigator will provide novel insights into mechanisms by which cells lining the air spaces of the lung initiate repair following injury. Advances in this area are relevant to a number of acute and chronic lung diseases and application of insights gained from these studies should lead to improvements in outcome in lung injury and disease.