Cardiovascular Molecular/Cellular Biology

描述（由申请人提供）：根据美国心脏协会，1/3的美国成年人患有心血管疾病（CVD）（超过8000万成年人），WHO指出CVD是全球头号死因。因此，尽管CVD治疗取得了重大进展，但它仍然是我国和世界的主要死亡原因。密苏里州大学（MU）的心血管健康和身体活动小组因其揭示运动对心血管疾病有益作用的分子、生化和生理机制的工作而获得了全国的认可。目前的申请将通过增加分子/细胞生物学家来加强这一优势，从而改善对心血管过程的最先进分子、生化和生理评估的整合。新的教员将适合四组心血管研究人员之一：1）心肌。2)血管生物学与运动3)微血管生物学和成像。4)神经-体液心血管控制已被纳入多个部门的长期培训计划。新聘请的教师将能够指导来自几个单位的研究生。职业发展是由一个指导委员会的高级研究人员谁作为一个资源，职业决策，研究审查和赠款和手稿的制定。在这个校园里，鼓励跨部门和部门的激烈互动。心血管细胞/分子生物学家的加入将建立在心血管科学的跨学科研究卓越的基础上，并进一步建立MU作为美国运动和心血管健康的首要研究和培训中心。这名教师将使用分子生物学和基因调控来研究CVD的基础，并因此形成合作联系，以促进他们的职业发展。心血管科学组的优秀研究人员，加上这位新的教员，将达到更高的国家卓越水平，揭示预防和治疗心血管疾病的基本机制。 MU的心血管研究人员处于有关运动/体育活动对心血管疾病影响的研究前沿。这是一个聘请一名在分子生物学和基因调控方面受过培训和感兴趣的研究人员的建议，重点是运动/体育活动在预防心血管疾病方面的重要性。这将创建一个新的教师职位，并增加1或2个研究人员职位。这些教师与新教师相结合，将揭示肌肉活动/运动如何有助于预防和治疗心血管疾病的基本机制

DESCRIPTION (provided by applicant): According to the American Heart Association, 1 in 3 American adults has cardiovascular disease (CVD) (over 80 million adults) and the WHO indicates that CVD is the number 1 cause of death worldwide. Thus despite major advances in treatment of CVD, it remains the leading cause of death in our nation and the world. The Cardiovascular Health and Physical Activity group here at University of Missouri (MU) has attracted national recognition for work revealing molecular, biochemical and physiological mechanisms underlying the beneficial effects of exercise on CVD. This current application will build on this strength by adding a molecular/cellular biologist and thereby improve integration of state-of the-art molecular, biochemical and physiological assessments of cardiovascular processes. The new faculty member will fit into one of four groups of cardiovascular researchers: 1) Cardiac Muscle. 2) Vascular Biology and Exercise. 3) Microvascular Biology and Imaging. 4) Neural-humoral Cardiovascular Control that are integrated into long-standing training programs in several departments. The newly-hired faculty member will be able to mentor graduate students from several units. Career development is fostered by a mentoring committee of senior investigators who serve as a resource for career decision, research review and grant and manuscript formulation. Intense interactions across departmental and divisional lines are encouraged and routine on this campus. The addition of a cardiovascular cellular/molecular biologist will build on the interdisciplinary research excellence in cardiovascular sciences and further establish MU as a premiere research and training center in the U.S. for Exercise and Cardiovascular Health. This faculty member will examine the basis of CVD using molecular biology, and gene regulation and as a result form collaborative links that will enhance their career development. The outstanding cadre of investigators here in the cardiovascular sciences group, combined with this new faculty member will attain an even higher level of national preeminence reveal fundamental mechanisms in prevention and treatment of CVD. Cardiovascular researchers at MU are at the forefront of research concerning the effects of exercise/physical activity on cardiovascular disease. This is a proposal to hire a researcher with training and interests in molecular biology, and gene regulation focused on the importance of exercise/ physical activity in preventing cardiovascular disease. This will create a new faculty position and add 1 or 2 research staff positions. These faculty, combined with the new faculty member, will reveal fundamental mechanisms in how muscle activity/exercise contribute to prevention and treatment of cardiovascular disease