The Anelastic Strain Response of Spine Rods in a Biologic Environment

描述(申请人提供)：利用科罗拉多矿业学院独特的冶金和材料专业知识，这项工作将寻求通过与骨科和科罗拉多大学丹佛医学院的合作，在模拟的人体环境中确定钛及其合金的止痛反应的性质。我们假设，钛及其合金对体内化学和微结构改变的敏感性会导致其材料特性的变化，从而导致椎弓根螺钉拔出或其他脊柱内固定失败。创建一个基础设施，使科罗拉多矿业学院的学生能够利用科罗拉多大学医学院的专业知识参与生物医学研究。这项工作将使用EDS和EBSD扫描电子显微镜成像、光学金相、X射线衍射和纳米压痕等材料分析技术来完成，脊柱棒的轮廓和放置在模拟人体环境中长达3个月。将积极招募本科生和研究生参与研究的各个方面。在这样做的过程中，科罗拉多矿业学院将向尚未获得的it专业知识的应用程序开放。 公共卫生相关性：利用科罗拉多矿业学院独特的冶金和材料专业知识，这项工作将通过与骨科和科罗拉多大学丹佛医学院合作，在模拟人体环境中确定钛及其合金的止痛反应的性质。我们假设，钛及其合金对体内化学和微结构改变的敏感性会导致其材料特性的变化，从而导致椎弓根螺钉拔出或其他脊柱内固定失败。

DESCRIPTION (provided by applicant): Utilizing the unique metallurgical and materials expertise at the Colorado School of Mines this work will seek to determine the nature of analeastic responses of titanium and its alloys in a simulated body environment via collaboration with the Department of Orthopedics and the University Of Colorado Denver School of Medicine. We hypothesize that susceptibility of titanium and it alloys to chemical and micro-structural modification from being in the body results in changes to its material properties that can cause pedicle screw pull-out or other spinal instrumentation failure. Create an infrastructure that enables students at the Colorado School of Mines to participate in biomedical research utilizing the expertise at the University of Colorado Medical School. This work will be accomplished using materials analytic techniques of SEM imaging with EDS and EBSD, optical metallographic, X-ray diffraction, and nano-indentation, of spine rods contoured and placed in a simulated body environment for up to 3 months. Undergraduate and graduate students will be actively recruited to be involved in all aspects of the research. In so doing it opens The Colorado School of Mines to applications of it expertise that have not been available. PUBLIC HEALTH RELEVANCE: Utilizing the unique metallurgical and materials expertise at the Colorado School of Mines this work will determine the nature of analeastic responses of titanium and its alloys in a simulated body environment via collaboration with the Department of Orthopedics and the University of Colorado Denver School of Medicine. We hypothesize that susceptibility of titanium and it alloys to chemical and micro-structural modification from being in the body results in changes to its material properties that can cause pedicle screw pull-out or other spinal instrumentation failure.