2010 "Synaptic Transmission" Gordon Research Conference

描述(由申请人提供)：本提案请求部分支持作为戈登研究会议系列的一部分的突触传输国际会议，该会议将于2010年7月25-30日在缅因州比德福德的美国大西洋海岸的新英格兰大学校区举行。会议的广泛和长期目标是增加我们对突触传递的基本分子和细胞机制的理解。突触是神经系统的基本信号单位。突触传递是大脑功能的各个方面的基础，与大多数神经疾病以及精神疾病和药物成瘾有关。这次会议的具体目标是召集代表突触传递研究关键领域的34位演讲者，总共140名与会者，在一个相对孤立的环境中举行为期五天的会议。该计划将有两次主旨讲座和八次会议，广泛讨论当前的问题，包括递质释放、突触后信号和受体贩运、短期和长期可塑性、跨突触信号、突触整合和电路、局部蛋白质合成和突触功能，以及一次专门讨论大脑疾病的突触基础的会议。此外，两个晚上的海报会议将允许所有参与者为这些主题做出贡献。这项申请的意义在于，戈登突触传播研究会议是每年一次的系列会议的关键组成部分，这些会议推动了国际社会对“突触专家”的研究。这一应用程序与健康相关的是，讨论将定义需要通过实验解决一系列破坏性大脑疾病的问题，包括神经退行性疾病、精神分裂症、自闭症谱系障碍、药物成瘾、情绪障碍和许多其他可以统称为突触病变的问题。 与公共健康相关：我们如何思考、感受、行为和学习，都依赖于一个被称为突触传递的过程，即神经细胞之间的信息传递。这一应用的与健康相关的是，当前突触传输研究的讨论将定义需要在影响广泛的破坏性大脑疾病的领域中实验解决的问题，包括神经退行性疾病，如帕金森氏病和阿尔茨海默病、精神分裂症、情绪障碍、自闭症谱系障碍、精神发育迟滞和药物成瘾。这些讨论将集中于研究人员确定正常和疾病状态下突触传递的机制，并基于这些机制开发治疗方法。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Synaptic Transmission as part of the Gordon Research Conference series to be held at the University of New England Campus on the US Atlantic coast in Biddeford, Maine during the week of July 25-30, 2010. The broad and long term goal of the conference is to increase our understanding of the fundamental molecular and cellular mechanisms of synaptic transmission. The synapse serves as the basic signaling unit of the nervous system. Synaptic transmission underlies every aspect of brain function and is relevant to most neurological diseases, as well as mental illness and drug addiction. The specific aims of this meeting will be to convene 34 speakers that represent critical areas of synaptic transmission research with a total of 140 participants for a five day conference in a relatively isolated setting. The program will have two keynote lectures and eight sessions that broadly address current issues in transmitter release, postsynaptic signaling and receptor trafficking, short- and long-term plasticity, trans-synaptic signaling, synaptic integration and circuits, local protein synthesis and synaptic function, and a session devoted to the synaptic basis of brain disorders. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference on Synaptic Transmission is a critical component of the yearly series of conferences that propel research in the international community of "synaptologists". The health relatedness of this application is that the discussions will define the questions that require experimental resolution of a wide range of devastating brain disorders, including neurodegenerative diseases, schizophrenia, autism spectrum disorders, drug addiction, mood disorders and many others, which can collectively be regarded as synaptopathies. PUBLIC HEALTH RELEVANCE: How we think, feel, act and learn, all rely on a process known as synaptic transmission, namely, the information transfer between nerve cells. The health relatedness of this application is that the discussions of current research in synaptic transmission will define the questions that require experimental resolution in areas that affect a wide range of devastating brain disorders, including neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, schizophrenia, mood disorders, autism spectrum disorders, mental retardation and drug addiction. These discussions will focus researchers identifying the mechanisms of synaptic transmission under normal and disease states, and developing therapies based on these mechanisms.