2010 Photosensory Receptors and Signal Transduction GRC/GRS

描述（由申请人提供）：感光受体和信号转导GRC会议是在光感受的机制基础和效果领域的杰出会议。自2000年成立以来，该会议每两年在美国和欧洲的地点交替举行，下一次会议定于2010年4月18日至23日在Il Ciocco举行，此前三次会议都使用了该地点。光传感器社区包括各种各样的领域。因此，本次会议的主要目的是为研究光探测的生物，化学和物理方面的研究人员提供相互分享他们的最新数据，而不是在更有限的亚社区内。在基因组测序工作提供的新可用光传感器爆炸的帮助下，该领域已经加入了新的光感受器家族和现有家族的许多新成员。总之，这些提供了一组不同的系统来回答蛋白质信号传导中的基本问题：小分子发色团如何触发周围蛋白质的变构变化？这些变化是如何传递到下游效应器的？这个过程的参数是如何调整的，以满足生物系统的需要？这些问题是人类生理学（例如视觉，昼夜节律）和细菌，植物和动物生物学的主要兴趣。此外，这些对于开发新的生物研究工具和对蛋白质结构/功能/调节的一般理解是重要的。 GRC会议包括口头报告和海报会议。口头报告以传统的GRC格式组织，在五天内举行九次会议，促进不同家庭的光感受器的比较讨论。演讲将由生物化学，生物物理学，细胞生物学，化学，微生物学，生理学和植物生物学领域的资深研究人员进行，并与新来者和具有特殊新成果的早期职业科学家混合。会议将由杰出的互动研究人员主持，他们将自己的专业知识结合演讲者的成果和该领域的主要问题。作为口头报告的补充，海报会议将为所有与会者提供机会，与该领域的其他成员介绍和讨论他们的发现。新到2010年的会议，我们将增加戈登研究研讨会组织和参加的，学生和博士后给额外的演示和网络机会，我们的社会这个关键群体。 公共卫生相关性：感光受体和信号转导GRC会议为感光领域的研究人员提供了一个论坛，以满足和讨论受体机制中共同感兴趣的问题。这个领域是非常多样化的，因为相同的光检测原理在生物学中广泛保存，因此需要一个整合这个社区的会议。这里讨论的问题是人类生理学（如视觉，昼夜节律），生物研究和蛋白质结构/功能/调节的一般理解的新工具的发展的核心利益。

DESCRIPTION (provided by applicant): The Photo sensory Receptors and Signal Transduction GRC meeting is the pre-eminent meeting in the field of the mechanistic basis and effects of photoreception. Having been established in 2000, the meeting alternates between US and European sites every two years, with the next meeting scheduled for April 18-23, 2010 at the Il Ciocco site used for three prior conferences. The photo sensor community encompasses a diverse variety of fields. For this reason, the primary objective of this meeting is to provide researchers studying the biological, chemical and physical aspects of light detection to share their newest data with each other rather than within more limited subcommunities. Aided by the explosion of newly-available photosensors provided by genomic sequencing efforts, this field has been joined by both new families of photoreceptors and a many new members of existing ones. Taken together, these provide a diverse group of systems to answer fundamental questions in protein signaling: How can small molecule chromophores trigger allosteric changes to surrounding proteins? How are these changes transmitted to downstream effectors? How are parameters of this process tuned to match the needs of the biological system? These questions are of central interest to human physiology (e.g. vision, circadian rhythms) and bacterial, plant and animal biology in general. Further, these are important to the development of novel biological research tools and general understanding of protein structure/function/regulation. The GRC meeting consists of both oral presentations and poster sessions. Oral presentations are organized in a conventional GRC format, with nine sessions over five days that facilitate comparative discussions of different families of photoreceptors. Presentations will be given by established investigators in the fields of biochemistry, biophysics, cell biology, chemistry, microbiology, physiology and plant biology, mixed with newcomers and early career scientists with exceptional new results. Sessions will be chaired by prominent and interactive researchers who bring their expertise to integrate results across speakers and in context of the major questions in the field. Complementing the oral presentations, poster sessions will provide opportunities for all attendees to present and discuss their findings with other members of the field. New to the 2010 meeting, we will add a Gordon Research Seminar organized and attended by, students and postdocs to give additional presentation and networking opportunities to this critical group of our community. PUBLIC HEALTH RELEVANCE: The Photo sensory Receptors and Signal Transduction GRC meeting provides a forum for researchers in the area of photoreception to meet and discuss issues of common interest in receptor mechanism. This field is extremely diverse, as the same principles of light detection are conserved widely across biology, and hence the need for a meeting which integrates this community. The issues discussed here are of central interest to human physiology (e.g. vision, circadian rhythms), the development of novel tools for biological research and general understanding of protein structure/function/regulation.