Molecular Neuroimaging Symposium

描述(由申请者提供)：拟议的为期两天的研讨会将汇集来自多个科学学科的个人，包括化学、工程、物理、分子生物学、神经科学和成像科学，目的是促进新兴的分子神经成像领域的发展。这次会议是在2009年在NIH举行的一次类似的会议之后举行的，会议的重点是心血管分子成像。上届会议吸引了200多名与会者和28幅海报演示。拟议中的会议旨在延续这一势头，并刺激分子成像领域的进一步增长。我们预计将吸引来自基础科学和临床社区的个人，特别强调鼓励初级科学家的参与。会议的总体结构将包括由该领域专家就集中主题进行的一系列说教讲座，就选定的关键领域进行小组讨论，以及摘要海报会议。本次研讨会将聚焦于中枢神经系统(CNS)靶向多模式成像的进展，并将涉及血脑屏障(BBB)、肿瘤、神经受体、干细胞、过继免疫疗法和其他与CNS相关的生物过程的成像。将重点放在发言者和登记者之间的互动上，以激发对这一领域的进一步兴趣，并促进参与者之间的合作。所有被邀请的演讲者将被要求提供2-3页的发言摘要，该摘要将提供给与会者并以电子方式分发。海报会议的摘要将发表在《核医学杂志》或《分子成像》上。这些会议记录将作为《核医学杂志》或《分子成像》的增刊发表。会议的目标是：1)教育科学界关于靶向多模式分子神经成像的潜力；2)概述与开发可跨越血脑屏障的靶向、监测和/或治疗中枢神经系统疾病的靶向示踪剂有关的关键问题；3)概述用于小动物成像和临床分子成像的各种成像技术；4)回顾干细胞和/或免疫细胞成像的方法和意义；5)确定神经受体成像和代谢过程成像的潜力；6)概述分子神经成像在改善我们对关键的中枢神经系统病理生理过程的理解和管理方面的潜力；7)促进分子成像的基础科学研究和中枢神经系统疾病的临床应用；8)促进在不同相关领域工作的科学家和临床医生之间的潜在合作；9)促进初级科学家和该领域更成熟的研究人员之间的互动。 与公共卫生相关：已经有了一种范式转变，以开发更基于分子的和个性化的方法来早期发现、监测和治疗中枢神经系统疾病(CNS)，目标是制定预防措施和控制不断上升的医疗保健成本。许多科学和临床领域的并行进展正在给生物标记物的开发、靶向诊断探针的设计和合成、药物发现和计算神经科学带来革命性的变化。个体化护理的另一个关键方面是通过在一系列空间尺度上应用非侵入性分子成像技术来获得感兴趣的病理过程的详细概况，基于新标记的靶向分子成像的应用可能与不同的分子/遗传表型相关联，此外还可以阐明可以为中枢神经系统疾病/障碍的治疗提供信息的病理生理学。拟议中的为期两天的研讨会将汇集来自多个科学学科的个人，包括化学、工程学、物理学、分子生物学、神经生理学和成像科学，目的是促进不断发展的翻译分子神经成像领域。

DESCRIPTION (provided by applicant): The proposed two-day symposium will bring together individuals from multiple scientific disciplines; including chemistry, engineering, physics, molecular biology, neurosciences, and imaging sciences with the goal of promoting the emerging field of molecular neuroimaging. This meeting follows a similar conference held at NIH in 2009 that focused on cardiovascular molecular imaging. The previous conference attracted over 200 participants and 28 poster presentations. The proposed meeting is designed to continue this momentum and stimulate further growth in the field of molecular imaging. We anticipate attracting individuals from both the basic science and clinical communities, with a special emphasis on encouraging the participation of junior scientists. The overall structure of the meeting will include a series of didactic lectures on focused topics by experts in the field, panel discussions on selected key areas, and an abstract poster session. This symposium will focus on advances in targeted multimodality imaging of the central nervous system (CNS) and will cover imaging of the blood-brain barrier (BBB), tumors, neuroreceptors, stem cells, adoptive immunotherapies, and other biological processes relevant to the CNS. There will be an emphasis on interactions among speakers and registrants to stimulate further interest in this field and foster collaborations between participants. All invited speakers will be required to provide a 2-3 page summary of their presentations which will be provided to the participants and distributed electronically. Abstracts from the poster session will be published in The Journal of Nuclear Medicine or Molecular Imaging. The proceedings will be published as a supplement to The Journal of Nuclear Medicine or Molecular Imaging. The objectives of the meeting are: 1) to educate the scientific community about the potential of targeted multimodality molecular neuroimaging; 2) to provide an overview of critical issues related to development of targeted tracers that can cross the BBB for targeting, monitoring, and/or treating CNS disease; 3) to provide an overview of various imaging technologies for both small animal imaging and clinical molecular imaging; 4) to review the approaches and implications for imaging of stem and/or immune cells; 5) to define the potential of neuroreceptor imaging and imaging of metabolic processes; 6) to provide an overview of the potential of molecular neuroimaging to improve our understanding and management of critical CNS pathophysiological processes, such as neurodegeneration, brain tumors, and psychiatric diseases; 7) to promote basic science research in molecular imaging and clinical applications for CNS disorders; 8) to foster potential collaborations among scientists and clinicians working in various related fields; 9) to stimulate interactions between junior scientists and more established investigators in the field. PUBLIC HEALTH RELEVANCE: There has been a paradigm shift towards the development of a more molecularly-based and personalized approach to the early detection, monitoring, and treatment of central nervous system diseases (CNS) with goals of developing preventive measures as well as controling the escalating costs of healthcare. Parallel advances in many scientific and clinical fields are revolutionizing biomarker development, the design and synthesis of targeted diagnostic probes, drug discovery, and computational neurosciences. Another key aspect of individualized care is obtaining a detailed profile of the pathologic processes of interest through the application of noninvasive molecular imaging technologies over a range of spatial scales, The application of targeted molecular imaging based on novel markers may be linked to distinct molecular/genetic phenotypes, in addition to elucidating pathophysiology that can inform the management of CNS disease/disorders. The proposed two-day symposium will bring together individuals from multiple scientific disciplines; including chemistry, engineering, physics, molecular biology, neurophysiology, and imaging sciences with the goal of promoting the evolving field of translational molecular neuroimaging.