International meeting on translational research for motor units

描述（由申请人提供）：脊髓运动神经元提供所有运动命令的输出，从而接收来自中枢神经系统中许多不同运动系统的输入，包括脊柱上和感觉。运动神经元直接与肌纤维相连，运动神经元的动作电位与其肌纤维的动作电位成正比。由于人体肌肉纤维的动作电位很容易评估，运动神经元是中枢神经系统中唯一的神经元，其放电模式可以很容易地在人体中测量。这些运动神经元放电模式有可能为人类在正常和疾病状态下中枢神经系统运动系统的功能提供深入的见解。在过去的9年里，一系列关于运动神经元的国际会议已经召开，目的是将研究动物制剂中运动神经元放电模式的细胞机制的研究人员与研究人类受试者中运动神经元放电模式的研究人员聚集在一起。本提案为学员（博士后和学生）参加该系列会议的第6次会议提供旅费支持，该会议名为“迈向运动神经元的转化研究”。这些运动神经元会议从2000年开始在美国和欧洲轮流举行。在这些会议上的相互作用在许多进步中是必不可少的，这些进步现在使该领域达到了开发新疗法的真正转化工作的门槛。这是将于2010年夏季（7月9日至13日）在法国巴黎笛卡尔大学举行的会议的主要焦点。这个会议非常受欢迎，为学员提供了很多演讲和讨论的机会。

DESCRIPTION (provided by applicant): Spinal motoneurons provide the output for all motor commands and thus receive inputs from many different motor systems in the CNS, both supraspinal and sensory. Motoneurons connect directly to muscle fibers and motoneuron action potentials are one to one with their muscle fiber action potentials. Because muscle fiber action potentials are easy to assess in human subjects, motoneurons are the only neurons in the CNS whose firing patterns can be readily measured in human subjects. These motoneuron firing patterns have the potential to provide deep insights into function in CNS motor systems in humans, in both normal and disease states. Over that past 9 years, a series of international meetings on motoneurons have been implemented with the goal of bringing together researchers who study cellular mechanism of motoneuron firing patterns in animal preparations with researchers who study motoneuron firing patterns in human subjects. This proposal is for travel support for trainees (post-docs and students) to attend the 6th meeting in this series, entitled "Towards Translational Research in Motoneurons". These motoneuron meetings have alternated between the United States and Europe from their inception in 2000. The interactions at these meeting have been essential in a number of advances that now bring the field to the threshold of true translational work to develop new therapies. This is the primary focus of the meeting that will occur at Universit¿ Paris Descartes, Paris, France in the summer of 2010 (July 9-13). The meeting has become very popular and offers many opportunities for presentations and discussions for trainees. PUBLIC HEALTH RELEVANCE: Motoneurons are the only cells in the CNS whose firing pattern can be measured in human subjects. The 6th international meeting on motoneuron, which will take place in the summer of 2010 at the University of Paris, provides trainees with many opportunities for presentation and discussion motoneurons in normal and disease states. This proposal seeks travel support for this purpose.