Meningioma: Risk Factors and Quality of Life

在美国国内还没有大规模研究检查过颅内疾病流行病学的任何方面 脑膜瘤是一种病变，占所有原发颅内肿瘤的25%。我们建议 在康涅狄格州进行脑膜瘤的人群病例/对照研究， 马萨诸塞州、北卡罗来纳州、德克萨斯州以及旧金山湾区 综合R01(请注意，所有五个地点都提交了相同的申请)。案件将被选中 使用快速病例确定，并将包括所有被诊断为 2006年7月1日起20至79岁经组织学确诊的颅内脑膜瘤 至2010年6月30日在上述地区。控制对象将通过随机数字拨号进行识别 方法并按性别、种族、地理位置和五岁年龄分类与病例匹配。 受试者将接受电话问卷调查，以收集关于这两个主要类别的信息 风险、暴露于电离辐射和荷尔蒙以及其他风险因素，如家族史 脑膜瘤和其他肿瘤、手机使用、头部创伤以及结果问题 和生活质量。对于病例受试者，将获得石蜡包埋的肿瘤组织块，以允许1) 统一的组织学检查，以及2)雌激素、孕激素、雄激素和 MIB-1受体。将从所有研究对象采集血液或口腔样本进行DNA测试 DNA修复和细胞周期基因的多态性。这项研究是第一次集中研究 检查脑膜瘤的环境和遗传危险因素。

No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will beselected using rapid case ascertainment and will include all male and female individuals diagnosed with a histologically confirmed intra-cranial meningioma betweenthe ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category.Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgenand MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentratedeffort to examine environmental and genetic risk factors for meningioma.