MR1 BIOCHEMICAL FEATURES AND IMMUNOLOGICAL FUNCTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 新的类I蛋白MR1在调节粘膜免疫中的作用是什么？MR1是哺乳动物中高度保守的MHC-I类蛋白，它通过不变的T细胞受体激活一组独特的T细胞。有趣的是，这些MR1激活的T细胞的发育依赖于肠道的共生菌群。我们的实验正在使用生化、细胞、转基因和结晶学方法来确定MR1蛋白的结构和功能。MS是代表跨校园、跨资源协作的方法之一。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. What is the function of the novel class-I-like protein, MR1, in regulating mucosal immunity? MR1 is highly conserved MHC-I-like protein in mammals, that activates a unique population of T cells with an invariant T cell receptor. Interestingly the development of these MR1 activated T cells is dependent upon the commensal flora of the gut. Our experiments are using biochemical, cellular, transgenic and crystallographic approaches to determine the structure and function of MR1 proteins. MS is one of the approaches that represents a cross-campus and cross-resource collaboration.