SYNTHETIC CHEMISTRY: MASS SPECTROMETRY FOR COMPOUND IDENTIFICATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究方向包括有机、无机和有机金属合成化学、过渡金属催化的不对称反应合成生物活性化合物、仿生化学、分子识别和材料化学。 在过去的几年中，他们加快了开发创新手性配体和新反应的努力。虽然他们已经发明了三种手性配体（PennPhos，BICP和Ambox），但Zhang小组开发了14种新配体（e.例如，在一个实施例中，Binaphane、ketalPhos、P、N配体、TunaPhos、DIOP*、FAP和TangPhos）。这些有效的配体进一步拓宽了许多不对称反应的范围，将有许多实际应用。 发展新的过渡金属催化反应是有机合成的重要任务。Zhang团队正在评估Rh催化的烯炔异构化，以在温和条件下仅提供1，4-二烯，并实现了第一个高度对映选择性的烯反应。 在金属催化的环化反应领域，Zhang等人首次发明了高对映选择性的银催化[3+2]环加成反应，合成了五元环含氮杂环化合物。这些杂环化合物可以容易地从现成的醛、氨基酯和亲偶极试剂制备。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Zhang group is interested in synthetic organic, inorganic and organometallic chemistry, transition metal catalyzed asymmetric reactions for the synthesis of biologically active compounds, biomimetic chemistry, molecular recognition and material chemistry. During the last few years, they accelerated effort in developing innovative chiral ligands and new reactions. While they already invented three chiral ligands (PennPhos, BICP and Ambox), the Zhang group developed fourteen new ligands (e. g., Binaphane, ketalPhos, P, N ligands, TunaPhos, DIOP*, FAP and TangPhos). These effective ligands further broaden the scope of many asymmetric reactions and will have many practical applications. Developing new transition metal-catalyzed reactions are important missions in organic synthesis. The Zhang group is evaluating Rh-catalyzed enyne isomerization to offer 1,4-dienes exclusively under a mild condition and the first highly enantioselective ene reaction was achieved. In the area of metal-catalyzed cyclization, the Zhang group has invented the first highly enantioselective Ag-catalyzed [3+2] cycloaddition for the synthesis of five-membered ring N-containing hetereocyclics. These hetereocyclics can be easily prepared from ready available aldehydes, aminoesters and dipolarphiles.