Centers for Cardiovascular Outcomes Research

描述(由申请人提供)：这份建议作为我们设想的NHBLI心血管结果研究计划中心(CCorp)的研究协调单位(RCU)来自阿拉巴马大学伯明翰分校预防医学部的合作研究中心(CSC)和结果和有效性研究与教育中心(Coere)。虽然CCorp需要从典型协调中心的操作中获得大部分可用内容，但由于它涵盖的范围相当广泛，因此带来了挑战 心血管疾病结果研究的主题和将要进行的研究的性质在#年是未知的。 提案准备工作。这意味着一个成功的RCU必须在心血管疾病和结果研究方面拥有广泛的专业知识，并且必须拥有设施和人员资源，为计划活动提供高质量、及时但高度适应性的支持。此外，CCorp作为一个整体，特别是RCU利用CCorp内部以及更广泛的CVD成果社区内的合作的能力，将在最大限度地发挥其影响方面发挥关键作用。拟议的CSC RCU团队及其整体设施和人员资源非常适合执行这项任务。领导层Person、Williams和Lewis博士在许多CVD和结果研究项目中拥有约50年的CC经验，其中几个项目专注于CVD结果研究。由于刘易斯博士在该领域的领导地位，该公司还在现场中心和临床中心拥有约15年的大规模临床试验和观察性研究经验。此外，CSC的全部资源和设施都是在过去15年中专门为这样的项目创建的，因此特别适合CCorp的挑战。我们的总体目标是与中心、研究委员会和NHLBI工作人员密切合作，提供CCorp蓬勃发展所需的RCU支持。我们的具体目标包括为研究管理提供优秀的基础设施；作为成果研究、成本效益、数据源、统计分析、质量保证计划和控制系统、数据管理和安全的资源；以及制定全面的指标来评估整个计划。

DESCRIPTION (provided by applicant): This proposal to serve as the Research Coordinating Unit (RCU) for what we envision as the NHBLI Centers for Cardiovascular Outcomes Research Program (CCORP) is from the Collaborative Studies Center (CSC) and the Center for Outcomes and Effectiveness Research and Education (COERE) of the University of Alabama at Birmingham Division of Preventive Medicine. While requiring much of what is available from the operations of a typical coordinating center, the CCORP presents challenges in that it covers the rather broad topic of CVD outcomes research and the nature of the research to be done is unknown at the time of proposal preparation. This means that a successful RCU must have broad expertise in CVD and outcomes research and must have the facility and personnel resources to provide high quality and timely but also highly adaptive support for Program activities. Also, the ability of the CCORP as a whole and of the RCU in particular to leverage collaborations within the CCORP as well as more broadly within the CVD outcomes community will play a critical part in maximizing its impact. The proposed CSC RCU team and its overall facility and personnel resources are unusually well suited for this task. The leadership, Drs. Person, Williams and Lewis has some 50 person years of CC experience over numerous CVD and outcomes research projects, several of which focused on CVD outcomes research. It also has some 15 additional years of experience with field center and clinical centers for large scale clinical trials and observational studies as a consequence of Dr. Lewis's leadership in this area. Further, the overall resources and facilities of the CSC have been created over the past 15 years specifically for projects such as this and thus is especially well suited for the CCORP challenges. Our general aim is to work closely with the centers, study committees, and NHLBI staff to provide RCU support as required for the CCORP to thrive. Our specific aims include providing an excellent infrastructure for study management; serving as a resource in outcomes research, cost effectiveness, data sources, statistical analyses, quality assurance plans and control systems, data management and security; and developing comprehensive metrics for evaluating the Program as a whole.