Annual Conference on Development of Robust Experimental Assay Methods (DREAM)

描述(申请人提供)：药物发现过程是寻找具有生物活性的分子的漫长旅程，目前只有粗略的地图可供指导。早期发现失败的教训很少被记录下来。由于NIH分子图书馆倡议等举措在学术筛选方面的增长，制药科学家现在已重新进入公共部门科学领域，并能够分享他们的专业知识。DREAM(开发稳健的实验分析方法)会议的目的是建立一个论坛，在这个论坛上，这些专家可以交流想法，吸取关键经验教训，并将知识和方案组织到药物发现过程早期阶段使用的发现分析指南中。这些早期阶段的分析对整个药物发现过程至关重要，因为它们往往设定了指导后续搜救工作的指南针。斯坦·菲尔兹在2001年出版的《科学》杂志上发表的一篇关于蛋白质组学的文章中明确阐述了改进自动发现分析的迫切需要。对于一个充斥着令人眼花缭乱的方法的领域来说，蛋白质组学的头号需求可能是新技术，这一点令人震惊。只是没有足够的分析方法足够简化，无法实现对相当于一个基因组的蛋白质进行必要的自动化。 与公共卫生相关：梦想会议将是一个独特的论坛，可以召集化学生物学和药物发现方面的编辑和国际主题专家来审查现有内容，并征求目前在NCGC网站上提供的分析指导手册的新内容。

DESCRIPTION (provided by applicant): The drug discovery process is a long journey of finding molecules with biological activity, and currently only crude maps are available for guidance. Lessons from failures in early discovery are rarely recorded. Due to growth in academic screening through initiatives such as the NIH Molecular Libraries Initiative, pharmaceutical scientists have now re-entered public sector science and are able to share their expertise and knowledge. The purpose of the DREAM (Development of Robust Experimental Assay Methods) conference is to establish a forum where such experts can exchange ideas, critical lesson learned, and organize knowledge and protocols in to a guide for discovery assays employed in the early phases of the drug discovery process. These early phase assays are critical to the entire drug discovery process as they often set the compass that guides subsequent SAR efforts. The urgent need for improved automated discovery assays was clearly articulated by Stan Fields in an article on proteomics in the Human Genome of issue of Science in 2001. "For a field so laden with razzmatazz methods, it is striking that the number one need in proteomics may be new technology. There are simply not enough assays that are sufficiently streamlined to allow the automation necessary to perform them on a genome's worth of proteins." PUBLIC HEALTH RELEVANCE: The DREAM conference will be a unique forum to convene editors & international subject matter experts in chemical biology & drug discovery to review existing content and solicit new content to the Assay Guidance Manual currently available on the NCGC website.